%0 Journal Article
%A Liu, Qi
%A Rubarth, Kerstin
%A Faber, Jennifer
%A Sulzer, Patricia
%A Dogan, Imis
%A Barkhoff, Miriam
%A Minnerop, Martina
%A Berlijn, Adam M
%A Elben, Saskia
%A Jacobi, Heike
%A Aktories, Julia-Elisabeth
%A Huvermann, Dana M
%A Erdlenbruch, Friedrich
%A Van der Veen, Raquel
%A Müller, Johanna
%A Nio, Enzo
%A Frank, Benedikt
%A Köhrmann, Martin
%A Wondzinski, Elke
%A Siebler, Mario
%A Reetz, Kathrin
%A Konczak, Jürgen
%A Konietschke, Frank
%A Klockgether, Thomas
%A Synofzik, Matthis
%A Röske, Sandra
%A Timmann, Dagmar
%A Thieme, Andreas
%T Subtypes of cognitive impairment in cerebellar disease identified by cross-diagnostic cluster-analysis: results from a German multicenter study.
%J Journal of neurology
%V 272
%N 1
%@ 0367-004X
%C Heidelberg
%I Springer
%M DZNE-2025-00027
%P 83
%D 2025
%X Cognitive and neuropsychiatric impairment, known as cerebellar cognitive affective syndrome (CCAS), may be present in cerebellar disorders. This study identified distinct CCAS subtypes in cerebellar patients using cluster analysis.The German CCAS-Scale (G-CCAS-S), a brief screening test for CCAS, was assessed in 205 cerebellar patients and 200 healthy controls. K-means cluster analysis was applied to G-CCAS-S data to identify cognitive clusters in patients. Demographic and clinical variables were used to characterize the clusters. Multiple linear regression quantified their relative contribution to cognitive performance. The ability of the G-CCAS-S to correctly distinguish between patients and controls was compared across the clusters.Two clusters explained the variance of cognitive performance in patients' best. Cluster 1 (30
%K Humans
%K Male
%K Female
%K Cognitive Dysfunction: diagnosis
%K Cognitive Dysfunction: etiology
%K Cognitive Dysfunction: physiopathology
%K Middle Aged
%K Germany: epidemiology
%K Cluster Analysis
%K Cerebellar Diseases: complications
%K Cerebellar Diseases: diagnosis
%K Cerebellar Diseases: physiopathology
%K Aged
%K Adult
%K Neuropsychological Tests
%K Cerebellar cognitive affective syndrome (CCAS) (Other)
%K Cerebellar disorders (Other)
%K Cluster analysis (Other)
%K German CCAS-Scale (Other)
%K Subgroups of CCAS (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:39708269
%2 pmc:PMC11663179
%R 10.1007/s00415-024-12831-1
%U https://pub.dzne.de/record/274046