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000274046 0247_ $$2ISSN$$a0340-5354
000274046 0247_ $$2ISSN$$a1432-1459
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000274046 041__ $$aEnglish
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000274046 1001_ $$0P:(DE-HGF)0$$aLiu, Qi$$b0
000274046 245__ $$aSubtypes of cognitive impairment in cerebellar disease identified by cross-diagnostic cluster-analysis: results from a German multicenter study.
000274046 260__ $$aHeidelberg$$bSpringer$$c2025
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000274046 520__ $$aCognitive and neuropsychiatric impairment, known as cerebellar cognitive affective syndrome (CCAS), may be present in cerebellar disorders. This study identified distinct CCAS subtypes in cerebellar patients using cluster analysis.The German CCAS-Scale (G-CCAS-S), a brief screening test for CCAS, was assessed in 205 cerebellar patients and 200 healthy controls. K-means cluster analysis was applied to G-CCAS-S data to identify cognitive clusters in patients. Demographic and clinical variables were used to characterize the clusters. Multiple linear regression quantified their relative contribution to cognitive performance. The ability of the G-CCAS-S to correctly distinguish between patients and controls was compared across the clusters.Two clusters explained the variance of cognitive performance in patients' best. Cluster 1 (30%) exhibited severe impairment. Cluster 2 (70%) displayed milder dysfunction and overlapped substantially with that of healthy controls. Cluster 1 patients were on average older, less educated, showed more severe ataxia and more extracerebellar involvement than cluster 2 patients. The cluster assignment predicted cognitive performance even after adjusting for all other covariates. The G-CCAS-S demonstrated good discriminative ability for cluster 1, but not for cluster 2.The variance of cognitive impairment in cerebellar disorders is best explained by one severely affected and one mildly affected cluster. Cognitive performance is not only predicted by demographic/clinical characteristics, but also by cluster assignment itself. This indicates that factors that have not been captured in this study likely have effects on cognitive cerebellar functions. Moreover, the CCAS-S appears to have a relative weakness in identifying patients with only mild cognitive deficits.The study has prospectively been registered at the German Clinical Study Register ( https://www.drks.de ; DRKS-ID: DRKS00016854).
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000274046 650_7 $$2Other$$aCerebellar cognitive affective syndrome (CCAS)
000274046 650_7 $$2Other$$aCerebellar disorders
000274046 650_7 $$2Other$$aCluster analysis
000274046 650_7 $$2Other$$aGerman CCAS-Scale
000274046 650_7 $$2Other$$aSubgroups of CCAS
000274046 650_2 $$2MeSH$$aHumans
000274046 650_2 $$2MeSH$$aMale
000274046 650_2 $$2MeSH$$aFemale
000274046 650_2 $$2MeSH$$aCognitive Dysfunction: diagnosis
000274046 650_2 $$2MeSH$$aCognitive Dysfunction: etiology
000274046 650_2 $$2MeSH$$aCognitive Dysfunction: physiopathology
000274046 650_2 $$2MeSH$$aMiddle Aged
000274046 650_2 $$2MeSH$$aGermany: epidemiology
000274046 650_2 $$2MeSH$$aCluster Analysis
000274046 650_2 $$2MeSH$$aCerebellar Diseases: complications
000274046 650_2 $$2MeSH$$aCerebellar Diseases: diagnosis
000274046 650_2 $$2MeSH$$aCerebellar Diseases: physiopathology
000274046 650_2 $$2MeSH$$aAged
000274046 650_2 $$2MeSH$$aAdult
000274046 650_2 $$2MeSH$$aNeuropsychological Tests
000274046 7001_ $$aRubarth, Kerstin$$b1
000274046 7001_ $$0P:(DE-2719)2811327$$aFaber, Jennifer$$b2$$udzne
000274046 7001_ $$0P:(DE-2719)2811919$$aSulzer, Patricia$$b3$$udzne
000274046 7001_ $$aDogan, Imis$$b4
000274046 7001_ $$0P:(DE-2719)2812114$$aBarkhoff, Miriam$$b5
000274046 7001_ $$aMinnerop, Martina$$b6
000274046 7001_ $$aBerlijn, Adam M$$b7
000274046 7001_ $$aElben, Saskia$$b8
000274046 7001_ $$aJacobi, Heike$$b9
000274046 7001_ $$aAktories, Julia-Elisabeth$$b10
000274046 7001_ $$aHuvermann, Dana M$$b11
000274046 7001_ $$aErdlenbruch, Friedrich$$b12
000274046 7001_ $$aVan der Veen, Raquel$$b13
000274046 7001_ $$aMüller, Johanna$$b14
000274046 7001_ $$aNio, Enzo$$b15
000274046 7001_ $$aFrank, Benedikt$$b16
000274046 7001_ $$aKöhrmann, Martin$$b17
000274046 7001_ $$aWondzinski, Elke$$b18
000274046 7001_ $$aSiebler, Mario$$b19
000274046 7001_ $$aReetz, Kathrin$$b20
000274046 7001_ $$aKonczak, Jürgen$$b21
000274046 7001_ $$aKonietschke, Frank$$b22
000274046 7001_ $$0P:(DE-2719)2810314$$aKlockgether, Thomas$$b23$$udzne
000274046 7001_ $$0P:(DE-2719)2811275$$aSynofzik, Matthis$$b24$$udzne
000274046 7001_ $$0P:(DE-2719)2810395$$aRöske, Sandra$$b25$$udzne
000274046 7001_ $$aTimmann, Dagmar$$b26
000274046 7001_ $$00000-0001-6221-8601$$aThieme, Andreas$$b27
000274046 773__ $$0PERI:(DE-600)1421299-7$$a10.1007/s00415-024-12831-1$$gVol. 272, no. 1, p. 83$$n1$$p83$$tJournal of neurology$$v272$$x0367-004X$$y2025
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