TY  - JOUR
AU  - Liu, Qi
AU  - Rubarth, Kerstin
AU  - Faber, Jennifer
AU  - Sulzer, Patricia
AU  - Dogan, Imis
AU  - Barkhoff, Miriam
AU  - Minnerop, Martina
AU  - Berlijn, Adam M
AU  - Elben, Saskia
AU  - Jacobi, Heike
AU  - Aktories, Julia-Elisabeth
AU  - Huvermann, Dana M
AU  - Erdlenbruch, Friedrich
AU  - Van der Veen, Raquel
AU  - Müller, Johanna
AU  - Nio, Enzo
AU  - Frank, Benedikt
AU  - Köhrmann, Martin
AU  - Wondzinski, Elke
AU  - Siebler, Mario
AU  - Reetz, Kathrin
AU  - Konczak, Jürgen
AU  - Konietschke, Frank
AU  - Klockgether, Thomas
AU  - Synofzik, Matthis
AU  - Röske, Sandra
AU  - Timmann, Dagmar
AU  - Thieme, Andreas
TI  - Subtypes of cognitive impairment in cerebellar disease identified by cross-diagnostic cluster-analysis: results from a German multicenter study.
JO  - Journal of neurology
VL  - 272
IS  - 1
SN  - 0367-004X
CY  - Heidelberg
PB  - Springer
M1  - DZNE-2025-00027
SP  - 83
PY  - 2025
AB  - Cognitive and neuropsychiatric impairment, known as cerebellar cognitive affective syndrome (CCAS), may be present in cerebellar disorders. This study identified distinct CCAS subtypes in cerebellar patients using cluster analysis.The German CCAS-Scale (G-CCAS-S), a brief screening test for CCAS, was assessed in 205 cerebellar patients and 200 healthy controls. K-means cluster analysis was applied to G-CCAS-S data to identify cognitive clusters in patients. Demographic and clinical variables were used to characterize the clusters. Multiple linear regression quantified their relative contribution to cognitive performance. The ability of the G-CCAS-S to correctly distinguish between patients and controls was compared across the clusters.Two clusters explained the variance of cognitive performance in patients' best. Cluster 1 (30
KW  - Humans
KW  - Male
KW  - Female
KW  - Cognitive Dysfunction: diagnosis
KW  - Cognitive Dysfunction: etiology
KW  - Cognitive Dysfunction: physiopathology
KW  - Middle Aged
KW  - Germany: epidemiology
KW  - Cluster Analysis
KW  - Cerebellar Diseases: complications
KW  - Cerebellar Diseases: diagnosis
KW  - Cerebellar Diseases: physiopathology
KW  - Aged
KW  - Adult
KW  - Neuropsychological Tests
KW  - Cerebellar cognitive affective syndrome (CCAS) (Other)
KW  - Cerebellar disorders (Other)
KW  - Cluster analysis (Other)
KW  - German CCAS-Scale (Other)
KW  - Subgroups of CCAS (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:39708269
C2  - pmc:PMC11663179
DO  - DOI:10.1007/s00415-024-12831-1
UR  - https://pub.dzne.de/record/274046
ER  -