% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Haeckert:274048,
      author       = {Haeckert, Jan and Roeh, Astrid and Karch, Susanne and
                      Koeglsperger, Thomas and Hasan, Alkomiet and Papazova,
                      Irina},
      title        = {{I}mpact of {P}arkinson {M}edication on {N}europsychiatric
                      and {N}eurocognitive {S}ymptoms in {P}atients with
                      {A}dvanced {P}arkinson {D}isease {P}rior to {D}eep {B}rain
                      {S}timulation.},
      journal      = {Pharmacopsychiatry},
      volume       = {58},
      number       = {1},
      issn         = {0176-3679},
      address      = {Stuttgart [u.a.]},
      publisher    = {Thieme},
      reportid     = {DZNE-2025-00029},
      pages        = {5 - 13},
      year         = {2025},
      abstract     = {This study evaluates the impact of Parkinson disease (PD)
                      medication in advanced PD on neuropsychological performance,
                      psychiatric symptoms, impulsivity and the quality of life.
                      In the 4-year period 27 patients with advanced PD, scheduled
                      for deep brain stimulation (DBS) surgery (N=27, mean age:
                      58.9±7.1, disease duration: 10.0 years±4.2) were examined
                      preoperatively. We hypothesized that a high dosage of PD
                      medication or current use of dopamine agonists affect
                      cognitive functioning and psychiatric wellbeing.We performed
                      two subgroup analyses with low versus high
                      levodopa-equivalent Dosage (LED) medication and without
                      versus with dopaminagonistic medication.The
                      neuropsychological testing revealed significant differences
                      in the verbal learn- and memory-test (VLMT) during the
                      learning passage (U=36.500, Z=- 2.475, p=0.012) and in the
                      subtest of the semantic fluency of Regensburg verbal fluency
                      test (RWT) (t(25)=- 2.066, p=0.049) with better results for
                      patients without dopaminagonistic medication. Pearson
                      correlation analyses of LED in correlation with the clinical
                      and cognitive dependent variables showed a significant
                      higher PANSS total score in patients with higher LED
                      medication (r=0.491, p=0.009). In addition, lower LED
                      treatment was associated with significant higher scores in
                      the impulsivity perseverance subtest (r=- 0.509, p=0.008).In
                      conclusion, we found lower LEDs to be correlated with a
                      better perseverance in the impulsivity test and additional
                      treatment with a dopamine agonist influenced some verbal
                      learning tasks and the PANSS total score in patients with
                      advanced PD. This should be considered prior to DBS
                      surgery.},
      keywords     = {Humans / Parkinson Disease: drug therapy / Parkinson
                      Disease: psychology / Parkinson Disease: complications /
                      Parkinson Disease: therapy / Deep Brain Stimulation / Male /
                      Middle Aged / Female / Neuropsychological Tests / Aged /
                      Antiparkinson Agents: therapeutic use / Quality of Life /
                      Dopamine Agonists: therapeutic use / Levodopa: therapeutic
                      use / Cognition: drug effects / Antiparkinson Agents (NLM
                      Chemicals) / Dopamine Agonists (NLM Chemicals) / Levodopa
                      (NLM Chemicals)},
      cin          = {Clinical Research (Munich)},
      ddc          = {610},
      cid          = {I:(DE-2719)1111015},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39572152},
      doi          = {10.1055/a-2446-6877},
      url          = {https://pub.dzne.de/record/274048},
}