%0 Journal Article
%A Barba, Lorenzo
%A Vollmuth, Christoph
%A Halbgebauer, Steffen
%A Ungethüm, Kathrin
%A Hametner, Christian
%A Essig, Fabian
%A Kollikowski, Alexander M
%A Pham, Mirko
%A Schuhmann, Michael K
%A Heuschmann, Peter U
%A Oeckl, Patrick
%A Steinacker, Petra
%A Romoli, Michele
%A D'Anna, Lucio
%A Abu-Rumeileh, Samir
%A Haeusler, Karl Georg
%A Stoll, Guido
%A Neugebauer, Hermann
%A Otto, Markus
%T Prognostic serum biomarkers of synaptic, neuronal and glial injury in patients with acute ischemic stroke of the anterior circulation.
%J European journal of neurology
%V 32
%N 1
%@ 1351-5101
%C Oxford [u.a.]
%I Wiley-Blackwell
%M DZNE-2025-00031
%P e16581
%D 2025
%X We aimed to investigate the prognostic role of β-synuclein in comparison to that of neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) for predicting functional outcome after acute ischemic stroke (AIS).We measured serum concentrations of β-synuclein, NfL and GFAP 24 h after hospital admission in 213 consecutive patients with moderate-to-severe AIS. We investigated the association between serum biomarkers and radiological/clinical characteristics, 3-months mortality and functional outcome on the modified Rankin Scale (mRS).In 213 patients with AIS [mean age: 76.1 (±12.5) years, 53.1
%K Humans
%K Male
%K Female
%K Aged
%K Biomarkers: blood
%K Ischemic Stroke: blood
%K Ischemic Stroke: mortality
%K Prognosis
%K Aged, 80 and over
%K Glial Fibrillary Acidic Protein: blood
%K Neurofilament Proteins: blood
%K Middle Aged
%K Neuroglia
%K Neurons: pathology
%K Synapses
%K GFAP (Other)
%K NfL (Other)
%K beta‐synuclein (Other)
%K biomarkers (Other)
%K stroke (Other)
%K Biomarkers (NLM Chemicals)
%K Glial Fibrillary Acidic Protein (NLM Chemicals)
%K neurofilament protein L (NLM Chemicals)
%K Neurofilament Proteins (NLM Chemicals)
%K GFAP protein, human (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:39714176
%2 pmc:PMC11664725
%R 10.1111/ene.16581
%U https://pub.dzne.de/record/274050