TY  - JOUR
AU  - Barba, Lorenzo
AU  - Vollmuth, Christoph
AU  - Halbgebauer, Steffen
AU  - Ungethüm, Kathrin
AU  - Hametner, Christian
AU  - Essig, Fabian
AU  - Kollikowski, Alexander M
AU  - Pham, Mirko
AU  - Schuhmann, Michael K
AU  - Heuschmann, Peter U
AU  - Oeckl, Patrick
AU  - Steinacker, Petra
AU  - Romoli, Michele
AU  - D'Anna, Lucio
AU  - Abu-Rumeileh, Samir
AU  - Haeusler, Karl Georg
AU  - Stoll, Guido
AU  - Neugebauer, Hermann
AU  - Otto, Markus
TI  - Prognostic serum biomarkers of synaptic, neuronal and glial injury in patients with acute ischemic stroke of the anterior circulation.
JO  - European journal of neurology
VL  - 32
IS  - 1
SN  - 1351-5101
CY  - Oxford [u.a.]
PB  - Wiley-Blackwell
M1  - DZNE-2025-00031
SP  - e16581
PY  - 2025
AB  - We aimed to investigate the prognostic role of β-synuclein in comparison to that of neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) for predicting functional outcome after acute ischemic stroke (AIS).We measured serum concentrations of β-synuclein, NfL and GFAP 24 h after hospital admission in 213 consecutive patients with moderate-to-severe AIS. We investigated the association between serum biomarkers and radiological/clinical characteristics, 3-months mortality and functional outcome on the modified Rankin Scale (mRS).In 213 patients with AIS [mean age: 76.1 (±12.5) years, 53.1
KW  - Humans
KW  - Male
KW  - Female
KW  - Aged
KW  - Biomarkers: blood
KW  - Ischemic Stroke: blood
KW  - Ischemic Stroke: mortality
KW  - Prognosis
KW  - Aged, 80 and over
KW  - Glial Fibrillary Acidic Protein: blood
KW  - Neurofilament Proteins: blood
KW  - Middle Aged
KW  - Neuroglia
KW  - Neurons: pathology
KW  - Synapses
KW  - GFAP (Other)
KW  - NfL (Other)
KW  - beta‐synuclein (Other)
KW  - biomarkers (Other)
KW  - stroke (Other)
KW  - Biomarkers (NLM Chemicals)
KW  - Glial Fibrillary Acidic Protein (NLM Chemicals)
KW  - neurofilament protein L (NLM Chemicals)
KW  - Neurofilament Proteins (NLM Chemicals)
KW  - GFAP protein, human (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:39714176
C2  - pmc:PMC11664725
DO  - DOI:10.1111/ene.16581
UR  - https://pub.dzne.de/record/274050
ER  -