%0 Journal Article
%A Aretz, Benjamin
%A Doblhammer, Gabriele
%A Heneka, Michael
%T The role of leukocytes in cognitive impairment due to long-term exposure to fine particulate matter: A large population-based mediation analysis.
%J Alzheimer's and dementia
%V 20
%N 12
%@ 1552-5260
%C Hoboken, NJ
%I Wiley
%M DZNE-2025-00032
%P 8715 - 8727
%D 2024
%X Our understanding of how fine particulate matter (PM2.5) impacts cognitive functioning is limited. Systemic inflammation processes may play a role in mediating this effect.This prospective cohort study used data from 66,254 participants aged 18+ between 2006 and 2015 from the Dutch Lifelines Cohort Study and Biobank. Causal mediation analysis was conducted to examine the impact of ambient PM2.5 exposure on cognitive processing time (CPT), using the change in white blood cell (WBC) count and its subtypes as potential mediators.Heightened PM2.5 exposure was associated with slower CPT (total effect = 81.76 × 10-3, 95
%K Humans
%K Particulate Matter: adverse effects
%K Male
%K Female
%K Cognitive Dysfunction
%K Prospective Studies
%K Middle Aged
%K Mediation Analysis
%K Leukocytes: drug effects
%K Environmental Exposure: adverse effects
%K Netherlands: epidemiology
%K Adult
%K Aged
%K Inflammation
%K Leukocyte Count
%K Air Pollution: adverse effects
%K Air Pollution: statistics & numerical data
%K Cohort Studies
%K Air Pollutants: adverse effects
%K causal mediation analysis (Other)
%K cognitive functioning (Other)
%K fine particulate matter (Other)
%K leukocytes (Other)
%K systemic inflammation (Other)
%K white blood cell count (Other)
%K Particulate Matter (NLM Chemicals)
%K Air Pollutants (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:39412000
%2 pmc:PMC11667545
%R 10.1002/alz.14320
%U https://pub.dzne.de/record/274051