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000274051 041__ $$aEnglish
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000274051 1001_ $$00000-0003-0143-0873$$aAretz, Benjamin$$b0
000274051 245__ $$aThe role of leukocytes in cognitive impairment due to long-term exposure to fine particulate matter: A large population-based mediation analysis.
000274051 260__ $$aHoboken, NJ$$bWiley$$c2024
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000274051 520__ $$aOur understanding of how fine particulate matter (PM2.5) impacts cognitive functioning is limited. Systemic inflammation processes may play a role in mediating this effect.This prospective cohort study used data from 66,254 participants aged 18+ between 2006 and 2015 from the Dutch Lifelines Cohort Study and Biobank. Causal mediation analysis was conducted to examine the impact of ambient PM2.5 exposure on cognitive processing time (CPT), using the change in white blood cell (WBC) count and its subtypes as potential mediators.Heightened PM2.5 exposure was associated with slower CPT (total effect = 81.76 × 10-3, 95% confidence interval [CI] 59.51 × 10-3-105.31 × 10-3). The effect was partially mediated via increased WBC count (indirect effect [IE] = 0.42 × 10-3, 95% CI 0.07 × 10-3-0.90 × 10-3), particularly driven by an increase in monocytes (IE = 0.73 × 10-3, 95% CI 0.24 × 10-3-1.31 × 10-3).Systemic inflammation processes may partially explain the harmful effects of PM2.5 on cognitive functioning, why lower levels of systemic inflammation may help contain its neurotoxic effects.The pathways leading to the neurotoxic effects of fine particulate matter (PM2.5) are poorly understood. We analyzed data from over 66,000 participants using causal pathway analysis. Increased white blood cell (WBC) count mediates the effect of PM2.5 on cognitive functioning. Monocyte count played a crucial role in this low-pollution setting. Systemic inflammation may contribute to the neurotoxic effects of PM2.5.
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000274051 650_7 $$2Other$$acausal mediation analysis
000274051 650_7 $$2Other$$acognitive functioning
000274051 650_7 $$2Other$$afine particulate matter
000274051 650_7 $$2Other$$aleukocytes
000274051 650_7 $$2Other$$asystemic inflammation
000274051 650_7 $$2Other$$awhite blood cell count
000274051 650_7 $$2NLM Chemicals$$aParticulate Matter
000274051 650_7 $$2NLM Chemicals$$aAir Pollutants
000274051 650_2 $$2MeSH$$aHumans
000274051 650_2 $$2MeSH$$aParticulate Matter: adverse effects
000274051 650_2 $$2MeSH$$aMale
000274051 650_2 $$2MeSH$$aFemale
000274051 650_2 $$2MeSH$$aCognitive Dysfunction
000274051 650_2 $$2MeSH$$aProspective Studies
000274051 650_2 $$2MeSH$$aMiddle Aged
000274051 650_2 $$2MeSH$$aMediation Analysis
000274051 650_2 $$2MeSH$$aLeukocytes: drug effects
000274051 650_2 $$2MeSH$$aEnvironmental Exposure: adverse effects
000274051 650_2 $$2MeSH$$aNetherlands: epidemiology
000274051 650_2 $$2MeSH$$aAdult
000274051 650_2 $$2MeSH$$aAged
000274051 650_2 $$2MeSH$$aInflammation
000274051 650_2 $$2MeSH$$aLeukocyte Count
000274051 650_2 $$2MeSH$$aAir Pollution: adverse effects
000274051 650_2 $$2MeSH$$aAir Pollution: statistics & numerical data
000274051 650_2 $$2MeSH$$aCohort Studies
000274051 650_2 $$2MeSH$$aAir Pollutants: adverse effects
000274051 7001_ $$0P:(DE-2719)2811246$$aDoblhammer, Gabriele$$b1
000274051 7001_ $$0P:(DE-2719)2000008$$aHeneka, Michael$$b2$$udzne
000274051 773__ $$0PERI:(DE-600)2201940-6$$a10.1002/alz.14320$$gVol. 20, no. 12, p. 8715 - 8727$$n12$$p8715 - 8727$$tAlzheimer's and dementia$$v20$$x1552-5260$$y2024
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