TY  - JOUR
AU  - Aretz, Benjamin
AU  - Doblhammer, Gabriele
AU  - Heneka, Michael
TI  - The role of leukocytes in cognitive impairment due to long-term exposure to fine particulate matter: A large population-based mediation analysis.
JO  - Alzheimer's and dementia
VL  - 20
IS  - 12
SN  - 1552-5260
CY  - Hoboken, NJ
PB  - Wiley
M1  - DZNE-2025-00032
SP  - 8715 - 8727
PY  - 2024
AB  - Our understanding of how fine particulate matter (PM2.5) impacts cognitive functioning is limited. Systemic inflammation processes may play a role in mediating this effect.This prospective cohort study used data from 66,254 participants aged 18+ between 2006 and 2015 from the Dutch Lifelines Cohort Study and Biobank. Causal mediation analysis was conducted to examine the impact of ambient PM2.5 exposure on cognitive processing time (CPT), using the change in white blood cell (WBC) count and its subtypes as potential mediators.Heightened PM2.5 exposure was associated with slower CPT (total effect = 81.76 × 10-3, 95
KW  - Humans
KW  - Particulate Matter: adverse effects
KW  - Male
KW  - Female
KW  - Cognitive Dysfunction
KW  - Prospective Studies
KW  - Middle Aged
KW  - Mediation Analysis
KW  - Leukocytes: drug effects
KW  - Environmental Exposure: adverse effects
KW  - Netherlands: epidemiology
KW  - Adult
KW  - Aged
KW  - Inflammation
KW  - Leukocyte Count
KW  - Air Pollution: adverse effects
KW  - Air Pollution: statistics & numerical data
KW  - Cohort Studies
KW  - Air Pollutants: adverse effects
KW  - causal mediation analysis (Other)
KW  - cognitive functioning (Other)
KW  - fine particulate matter (Other)
KW  - leukocytes (Other)
KW  - systemic inflammation (Other)
KW  - white blood cell count (Other)
KW  - Particulate Matter (NLM Chemicals)
KW  - Air Pollutants (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:39412000
C2  - pmc:PMC11667545
DO  - DOI:10.1002/alz.14320
UR  - https://pub.dzne.de/record/274051
ER  -