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000274053 1001_ $$00000-0001-6110-5824$$aHausmann, Fabian$$b0
000274053 245__ $$aA dataset profiling the multiomic landscape of the prefrontal cortex in amyotrophic lateral sclerosis.
000274053 260__ $$aOxford$$bOxford University Press$$c2024
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000274053 520__ $$aAmyotrophic lateral sclerosis (ALS) is the most common motor neuron disease, which still lacks effective disease-modifying therapies. Similar to other neurodegenerative disorders, such as Alzheimer and Parkinson disease, ALS pathology is presumed to propagate over time, originating from the motor cortex and spreading to other cortical regions. Exploring early disease stages is crucial to understand the causative molecular changes underlying the pathology. For this, we sampled human postmortem prefrontal cortex (PFC) tissue from Brodmann area 6, an area that exhibits only moderate pathology at the time of death, and performed a multiomic analysis of 51 patients with sporadic ALS and 50 control subjects. To compare sporadic disease to genetic ALS, we additionally analyzed PFC tissue from 4 transgenic ALS mouse models (C9orf72-, SOD1-, TDP-43-, and FUS-ALS) using the same methods. This multiomic data resource includes transcriptome, small RNAome, and proteome data from female and male samples, aimed at elucidating early and sex-specific ALS mechanisms, biomarkers, and drug targets.
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000274053 650_7 $$2Other$$aamyotrophic lateral sclerosis
000274053 650_7 $$2Other$$aearly disease mechanisms
000274053 650_7 $$2Other$$amultiomics analysis
000274053 650_7 $$2Other$$aneurodegeneration
000274053 650_7 $$2Other$$aprefrontal cortex
000274053 650_7 $$2NLM Chemicals$$aProteome
000274053 650_2 $$2MeSH$$aAmyotrophic Lateral Sclerosis: genetics
000274053 650_2 $$2MeSH$$aAmyotrophic Lateral Sclerosis: metabolism
000274053 650_2 $$2MeSH$$aPrefrontal Cortex: metabolism
000274053 650_2 $$2MeSH$$aPrefrontal Cortex: pathology
000274053 650_2 $$2MeSH$$aHumans
000274053 650_2 $$2MeSH$$aFemale
000274053 650_2 $$2MeSH$$aMice
000274053 650_2 $$2MeSH$$aMale
000274053 650_2 $$2MeSH$$aAnimals
000274053 650_2 $$2MeSH$$aMice, Transgenic
000274053 650_2 $$2MeSH$$aTranscriptome
000274053 650_2 $$2MeSH$$aProteome
000274053 650_2 $$2MeSH$$aDisease Models, Animal
000274053 650_2 $$2MeSH$$aAged
000274053 650_2 $$2MeSH$$aGene Expression Profiling: methods
000274053 650_2 $$2MeSH$$aMiddle Aged
000274053 7001_ $$00000-0003-4959-2169$$aCaldi Gomes, Lucas$$b1
000274053 7001_ $$00000-0003-4953-0101$$aHänzelmann, Sonja$$b2
000274053 7001_ $$00009-0006-5311-1718$$aKhatri, Robin$$b3
000274053 7001_ $$00000-0002-8994-1549$$aOller, Sergio$$b4
000274053 7001_ $$00009-0001-4696-3799$$aGebelin, Marie$$b5
000274053 7001_ $$00000-0002-0644-5559$$aParvaz, Mojan$$b6
000274053 7001_ $$00009-0003-7643-3232$$aTzeplaeff, Laura$$b7
000274053 7001_ $$00000-0003-0319-4448$$aPasetto, Laura$$b8
000274053 7001_ $$0P:(DE-2719)2811347$$aZhou, Qihui$$b9$$udzne
000274053 7001_ $$00009-0008-6776-663X$$aZelina, Pavol$$b10
000274053 7001_ $$0P:(DE-2719)2231621$$aEdbauer, Dieter$$b11
000274053 7001_ $$00000-0003-1631-6440$$aPasterkamp, R Jeroen$$b12
000274053 7001_ $$00000-0001-7612-9394$$aRehrauer, Hubert$$b13
000274053 7001_ $$00000-0002-7488-4262$$aSchlapbach, Ralph$$b14
000274053 7001_ $$00000-0002-0079-319X$$aCarapito, Christine$$b15
000274053 7001_ $$00000-0003-0456-2054$$aBonetto, Valentina$$b16
000274053 7001_ $$0P:(DE-2719)2810547$$aBonn, Stefan$$b17
000274053 7001_ $$0P:(DE-2719)2812561$$aLingor, Paul$$b18$$eLast author
000274053 773__ $$0PERI:(DE-600)2708999-X$$a10.1093/gigascience/giae100$$gVol. 13, p. giae100$$pgiae100$$tGigaScience$$v13$$x2047-217X$$y2024
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