TY  - JOUR
AU  - Hausmann, Fabian
AU  - Caldi Gomes, Lucas
AU  - Hänzelmann, Sonja
AU  - Khatri, Robin
AU  - Oller, Sergio
AU  - Gebelin, Marie
AU  - Parvaz, Mojan
AU  - Tzeplaeff, Laura
AU  - Pasetto, Laura
AU  - Zhou, Qihui
AU  - Zelina, Pavol
AU  - Edbauer, Dieter
AU  - Pasterkamp, R Jeroen
AU  - Rehrauer, Hubert
AU  - Schlapbach, Ralph
AU  - Carapito, Christine
AU  - Bonetto, Valentina
AU  - Bonn, Stefan
AU  - Lingor, Paul
TI  - A dataset profiling the multiomic landscape of the prefrontal cortex in amyotrophic lateral sclerosis.
JO  - GigaScience
VL  - 13
SN  - 2047-217X
CY  - Oxford
PB  - Oxford University Press
M1  - DZNE-2025-00034
SP  - giae100
PY  - 2024
AB  - Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease, which still lacks effective disease-modifying therapies. Similar to other neurodegenerative disorders, such as Alzheimer and Parkinson disease, ALS pathology is presumed to propagate over time, originating from the motor cortex and spreading to other cortical regions. Exploring early disease stages is crucial to understand the causative molecular changes underlying the pathology. For this, we sampled human postmortem prefrontal cortex (PFC) tissue from Brodmann area 6, an area that exhibits only moderate pathology at the time of death, and performed a multiomic analysis of 51 patients with sporadic ALS and 50 control subjects. To compare sporadic disease to genetic ALS, we additionally analyzed PFC tissue from 4 transgenic ALS mouse models (C9orf72-, SOD1-, TDP-43-, and FUS-ALS) using the same methods. This multiomic data resource includes transcriptome, small RNAome, and proteome data from female and male samples, aimed at elucidating early and sex-specific ALS mechanisms, biomarkers, and drug targets.
KW  - Amyotrophic Lateral Sclerosis: genetics
KW  - Amyotrophic Lateral Sclerosis: metabolism
KW  - Prefrontal Cortex: metabolism
KW  - Prefrontal Cortex: pathology
KW  - Humans
KW  - Female
KW  - Mice
KW  - Male
KW  - Animals
KW  - Mice, Transgenic
KW  - Transcriptome
KW  - Proteome
KW  - Disease Models, Animal
KW  - Aged
KW  - Gene Expression Profiling: methods
KW  - Middle Aged
KW  - amyotrophic lateral sclerosis (Other)
KW  - early disease mechanisms (Other)
KW  - multiomics analysis (Other)
KW  - neurodegeneration (Other)
KW  - prefrontal cortex (Other)
KW  - Proteome (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:39693632
C2  - pmc:PMC11653894
DO  - DOI:10.1093/gigascience/giae100
UR  - https://pub.dzne.de/record/274053
ER  -