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001     274053
005     20250119000303.0
024 7 _ |a 10.1093/gigascience/giae100
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082 _ _ |a 610
100 1 _ |a Hausmann, Fabian
|0 0000-0001-6110-5824
|b 0
245 _ _ |a A dataset profiling the multiomic landscape of the prefrontal cortex in amyotrophic lateral sclerosis.
260 _ _ |a Oxford
|c 2024
|b Oxford University Press
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520 _ _ |a Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease, which still lacks effective disease-modifying therapies. Similar to other neurodegenerative disorders, such as Alzheimer and Parkinson disease, ALS pathology is presumed to propagate over time, originating from the motor cortex and spreading to other cortical regions. Exploring early disease stages is crucial to understand the causative molecular changes underlying the pathology. For this, we sampled human postmortem prefrontal cortex (PFC) tissue from Brodmann area 6, an area that exhibits only moderate pathology at the time of death, and performed a multiomic analysis of 51 patients with sporadic ALS and 50 control subjects. To compare sporadic disease to genetic ALS, we additionally analyzed PFC tissue from 4 transgenic ALS mouse models (C9orf72-, SOD1-, TDP-43-, and FUS-ALS) using the same methods. This multiomic data resource includes transcriptome, small RNAome, and proteome data from female and male samples, aimed at elucidating early and sex-specific ALS mechanisms, biomarkers, and drug targets.
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650 _ 7 |a amyotrophic lateral sclerosis
|2 Other
650 _ 7 |a early disease mechanisms
|2 Other
650 _ 7 |a multiomics analysis
|2 Other
650 _ 7 |a neurodegeneration
|2 Other
650 _ 7 |a prefrontal cortex
|2 Other
650 _ 7 |a Proteome
|2 NLM Chemicals
650 _ 2 |a Amyotrophic Lateral Sclerosis: genetics
|2 MeSH
650 _ 2 |a Amyotrophic Lateral Sclerosis: metabolism
|2 MeSH
650 _ 2 |a Prefrontal Cortex: metabolism
|2 MeSH
650 _ 2 |a Prefrontal Cortex: pathology
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Female
|2 MeSH
650 _ 2 |a Mice
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Mice, Transgenic
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650 _ 2 |a Transcriptome
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650 _ 2 |a Proteome
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650 _ 2 |a Disease Models, Animal
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650 _ 2 |a Aged
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650 _ 2 |a Gene Expression Profiling: methods
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650 _ 2 |a Middle Aged
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700 1 _ |a Caldi Gomes, Lucas
|0 0000-0003-4959-2169
|b 1
700 1 _ |a Hänzelmann, Sonja
|0 0000-0003-4953-0101
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700 1 _ |a Khatri, Robin
|0 0009-0006-5311-1718
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700 1 _ |a Oller, Sergio
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700 1 _ |a Gebelin, Marie
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700 1 _ |a Parvaz, Mojan
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700 1 _ |a Tzeplaeff, Laura
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700 1 _ |a Pasetto, Laura
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700 1 _ |a Zhou, Qihui
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700 1 _ |a Zelina, Pavol
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700 1 _ |a Edbauer, Dieter
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700 1 _ |a Pasterkamp, R Jeroen
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700 1 _ |a Rehrauer, Hubert
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700 1 _ |a Schlapbach, Ralph
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700 1 _ |a Carapito, Christine
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700 1 _ |a Bonetto, Valentina
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700 1 _ |a Bonn, Stefan
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700 1 _ |a Lingor, Paul
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773 _ _ |a 10.1093/gigascience/giae100
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