000274063 001__ 274063
000274063 005__ 20250119000314.0
000274063 0247_ $$2doi$$a10.1073/pnas.2414176121
000274063 0247_ $$2pmid$$apmid:39693350
000274063 0247_ $$2pmc$$apmc:PMC11670061
000274063 0247_ $$2ISSN$$a0027-8424
000274063 0247_ $$2ISSN$$a1091-6490
000274063 0247_ $$2altmetric$$aaltmetric:172263114
000274063 037__ $$aDZNE-2025-00044
000274063 041__ $$aEnglish
000274063 082__ $$a500
000274063 1001_ $$0P:(DE-2719)2812532$$aChakraborty, Pijush$$b0$$udzne
000274063 245__ $$aGSK3β phosphorylation catalyzes the aggregation of tau into Alzheimer's disease-like filaments.
000274063 260__ $$aWashington, DC$$bNational Acad. of Sciences$$c2024
000274063 3367_ $$2DRIVER$$aarticle
000274063 3367_ $$2DataCite$$aOutput Types/Journal article
000274063 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1736344502_19585
000274063 3367_ $$2BibTeX$$aARTICLE
000274063 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000274063 3367_ $$00$$2EndNote$$aJournal Article
000274063 520__ $$aThe pathological deposition of proteins is a hallmark of several devastating neurodegenerative diseases. These pathological deposits comprise aggregates of proteins that adopt distinct structures named strains. However, the molecular factors responsible for the formation of distinct aggregate strains are unknown. Here, we show that the serine/threonine kinase GSK3β catalyzes the aggregation of the protein tau into Alzheimer's disease (AD)-like filaments. We demonstrate that phosphorylation by GSK3β, but not by several other kinases, promotes the aggregation of full-length tau as well as enhances phase separation into gel-like condensate structures. Cryoelectron microscopy further reveals that the fibrils formed by GSK3β-phosphorylated tau adopt a fold comparable to that of paired helical filaments isolated from the brains of AD patients. Our results elucidate the intricate relationship between posttranslational modification and the formation of tau strains in neurodegenerative diseases.
000274063 536__ $$0G:(DE-HGF)POF4-352$$a352 - Disease Mechanisms (POF4-352)$$cPOF4-352$$fPOF IV$$x0
000274063 588__ $$aDataset connected to CrossRef, PubMed, , Journals: pub.dzne.de
000274063 650_7 $$2Other$$aAlzheimer's disease
000274063 650_7 $$2Other$$aNMR
000274063 650_7 $$2Other$$acryo-EM
000274063 650_7 $$2Other$$aphosphorylation
000274063 650_7 $$2Other$$atau
000274063 650_7 $$2NLM Chemicals$$atau Proteins
000274063 650_7 $$0EC 2.7.11.1$$2NLM Chemicals$$aGlycogen Synthase Kinase 3 beta
000274063 650_7 $$2NLM Chemicals$$aMAPT protein, human
000274063 650_7 $$2NLM Chemicals$$aProtein Aggregates
000274063 650_7 $$0EC 2.7.11.1$$2NLM Chemicals$$aGSK3B protein, human
000274063 650_2 $$2MeSH$$atau Proteins: metabolism
000274063 650_2 $$2MeSH$$aAlzheimer Disease: metabolism
000274063 650_2 $$2MeSH$$aAlzheimer Disease: pathology
000274063 650_2 $$2MeSH$$aPhosphorylation
000274063 650_2 $$2MeSH$$aHumans
000274063 650_2 $$2MeSH$$aGlycogen Synthase Kinase 3 beta: metabolism
000274063 650_2 $$2MeSH$$aProtein Aggregation, Pathological: metabolism
000274063 650_2 $$2MeSH$$aProtein Processing, Post-Translational
000274063 650_2 $$2MeSH$$aBrain: metabolism
000274063 650_2 $$2MeSH$$aBrain: pathology
000274063 650_2 $$2MeSH$$aCryoelectron Microscopy
000274063 650_2 $$2MeSH$$aProtein Aggregates
000274063 7001_ $$0P:(DE-2719)2812657$$aIbáñez de Opakua, Alain$$b1
000274063 7001_ $$0P:(DE-2719)9001594$$aPurslow, Jeffrey$$b2$$udzne
000274063 7001_ $$00000-0002-2094-1911$$aFromm, Simon A$$b3
000274063 7001_ $$0P:(DE-2719)9002139$$aChatterjee, Debdeep$$b4
000274063 7001_ $$0P:(DE-2719)9001567$$aZachrdla, Milan$$b5$$udzne
000274063 7001_ $$0P:(DE-2719)9002416$$aZhuang, Shannon$$b6
000274063 7001_ $$00009-0003-1991-3977$$aPuri, Sambhavi$$b7
000274063 7001_ $$00000-0003-2068-1475$$aWolozin, Benjamin$$b8
000274063 7001_ $$0P:(DE-2719)2810591$$aZweckstetter, Markus$$b9$$eLast author
000274063 773__ $$0PERI:(DE-600)1461794-8$$a10.1073/pnas.2414176121$$gVol. 121, no. 52, p. e2414176121$$n52$$pe2414176121$$tProceedings of the National Academy of Sciences of the United States of America$$v121$$x0027-8424$$y2024
000274063 8564_ $$uhttps://pub.dzne.de/record/274063/files/DZNE-2025-00044.pdf$$yOpenAccess
000274063 8564_ $$uhttps://pub.dzne.de/record/274063/files/DZNE-2025-00044.pdf?subformat=pdfa$$xpdfa$$yOpenAccess
000274063 909CO $$ooai:pub.dzne.de:274063$$pdnbdelivery$$pdriver$$pVDB$$popen_access$$popenaire
000274063 9101_ $$0I:(DE-HGF)0$$6P:(DE-2719)2812532$$aExternal Institute$$b0$$kExtern
000274063 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2812657$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b1$$kDZNE
000274063 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9001594$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b2$$kDZNE
000274063 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9002139$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b4$$kDZNE
000274063 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9001567$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b5$$kDZNE
000274063 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9002416$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b6$$kDZNE
000274063 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2810591$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b9$$kDZNE
000274063 9131_ $$0G:(DE-HGF)POF4-352$$1G:(DE-HGF)POF4-350$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lNeurodegenerative Diseases$$vDisease Mechanisms$$x0
000274063 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2023-08-26
000274063 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2023-08-26
000274063 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2023-08-26
000274063 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2023-08-26
000274063 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2023-08-26
000274063 915__ $$0StatID:(DE-HGF)1040$$2StatID$$aDBCoverage$$bZoological Record$$d2023-08-26
000274063 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bP NATL ACAD SCI USA : 2022$$d2023-08-26
000274063 915__ $$0StatID:(DE-HGF)9910$$2StatID$$aIF >= 10$$bP NATL ACAD SCI USA : 2022$$d2023-08-26
000274063 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2023-08-26
000274063 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2023-08-26
000274063 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2023-08-26
000274063 915__ $$0LIC:(DE-HGF)CCBY4$$2HGFVOC$$aCreative Commons Attribution CC BY 4.0
000274063 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
000274063 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2023-08-26
000274063 915__ $$0StatID:(DE-HGF)1060$$2StatID$$aDBCoverage$$bCurrent Contents - Agriculture, Biology and Environmental Sciences$$d2023-08-26
000274063 915__ $$0StatID:(DE-HGF)0430$$2StatID$$aNational-Konsortium$$d2023-08-26$$wger
000274063 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2023-08-26
000274063 915__ $$0StatID:(DE-HGF)0320$$2StatID$$aDBCoverage$$bPubMed Central$$d2023-08-26
000274063 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2023-08-26
000274063 9201_ $$0I:(DE-2719)1410001$$kAG Zweckstetter$$lTranslational Structural Biology$$x0
000274063 980__ $$ajournal
000274063 980__ $$aVDB
000274063 980__ $$aUNRESTRICTED
000274063 980__ $$aI:(DE-2719)1410001
000274063 9801_ $$aFullTexts