TY  - JOUR
AU  - Collij, Lyduine E
AU  - Bischof, Gérard N
AU  - Altomare, Daniele
AU  - Bader, Ilse
AU  - Battle, Mark
AU  - Vállez García, David
AU  - Lopes Alves, Isadora
AU  - Wolz, Robin
AU  - Gismondi, Rossella
AU  - Stephens, Andrew
AU  - Walker, Zuzana
AU  - Scheltens, Philip
AU  - Nordberg, Agneta
AU  - Gispert, Juan Domingo
AU  - Drzezga, Alexander
AU  - Perissinotti, Andrés
AU  - Morbelli, Silvia
AU  - Buckley, Christopher
AU  - Garibotto, Valentina
AU  - Frisoni, Giovanni B
AU  - Farrar, Gill
AU  - Barkhof, Frederik
TI  - Quantification Supports Amyloid PET Visual Assessment of Challenging Cases: Results from the AMYPAD Diagnostic and Patient Management Study.
JO  - Journal of nuclear medicine
VL  - 66
IS  - 1
SN  - 0097-9058
CY  - New York, NY
PB  - Soc.
M1  - DZNE-2025-00046
SP  - 110 - 116
PY  - 2025
AB  - Several studies have demonstrated strong agreement between routine clinical visual assessment and quantification, suggesting that quantification approaches could support assessment by less experienced readers or in challenging cases. However, all studies to date have implemented a retrospective case collection, and challenging cases were generally underrepresented. Methods: We included all participants (n = 741) from the AMYPAD diagnostic and patient management study with available baseline amyloid PET quantification. Quantification was done with the PET-only AmyPype pipeline, providing global Centiloid and regional z scores. Visual assessment was performed by local readers for the entire cohort. From the total cohort, we selected a subsample of 85 cases for which the amyloid status based on the local reader's visual assessment and the Centiloid classification (cutoff = 21) was discordant or that were assessed with low confidence (i.e., ≤3 on a 5-point scale) by the local reader. In addition, concordant negative (n = 8) and positive (n = 8) scans across tracers were selected. In this sample (n = 101 cases; [18F]flutemetamol, n = 48; [18F]florbetaben, n = 53), the visual assessments and corresponding confidence by 5 certified independent central readers were captured before and after disclosure of the quantification results. Results: For the whole AMYPAD diagnostic and patient management study cohort, overall assessment by local readers highly agreed with Centiloid status (κ = 0.85, 92.3
KW  - Humans
KW  - Positron-Emission Tomography
KW  - Male
KW  - Female
KW  - Aged
KW  - Amyloid: metabolism
KW  - Retrospective Studies
KW  - Alzheimer Disease: diagnostic imaging
KW  - Middle Aged
KW  - Image Processing, Computer-Assisted
KW  - Alzheimer (Other)
KW  - Centiloid quantification (Other)
KW  - amyloid PET (Other)
KW  - molecular imaging (Other)
KW  - neurology (Other)
KW  - visual read (Other)
KW  - Amyloid (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:39542700
C2  - pmc:PMC11705786
DO  - DOI:10.2967/jnumed.124.268119
UR  - https://pub.dzne.de/record/274065
ER  -