%0 Journal Article
%A Michno, Manuel
%A Schmitz, Jan
%A Foerges, Anna L
%A Beer, Simone
%A Jordan, Jens
%A Neumaier, Bernd
%A Drzezga, Alexander
%A Aeschbach, Daniel
%A Bauer, Andreas
%A Tank, Jens
%A Weis, Henning
%A Elmenhorst, Eva-Maria
%A Elmenhorst, David
%T Effect of Acute Hypoxia Exposure on the Availability of A1 Adenosine Receptors and Perfusion in the Human Brain.
%J Journal of nuclear medicine
%V 66
%N 1
%@ 0097-9058
%C New York, NY
%I Soc.
%M DZNE-2025-00047
%P 142 - 149
%D 2025
%X In animal studies it has been observed that the inhibitory neuromodulator adenosine is released into the cerebral interstitial space during hypoxic challenges. Adenosine's actions on the A1 adenosine receptor (A1AR) protect the brain from oxygen deprivation and overexertion through adjustments in cerebral blood flow, metabolism, and electric activity. Methods: Using 8-cyclopentyl-3-(3-[18F]fluoropropyl)-1-propylxanthine ([18F]CPFPX), a PET tracer for the A1AR, we tested the hypothesis that hypoxia-induced adenosine release reduces A1AR availability in the human brain. Furthermore, we investigated whether this response is associated with altered brain perfusion and psychomotor vigilance. Ten healthy volunteers completed a 110-min bolus-plus-constant-infusion [18F]CPFPX PET/MRI hybrid experiment including a 30-min interval of normobaric hypoxia with peripheral oxygen saturation between 70
%K Humans
%K Male
%K Receptor, Adenosine A1: metabolism
%K Adult
%K Brain: diagnostic imaging
%K Brain: metabolism
%K Brain: blood supply
%K Female
%K Positron-Emission Tomography
%K Cerebrovascular Circulation
%K Hypoxia: metabolism
%K Hypoxia: physiopathology
%K Hypoxia: diagnostic imaging
%K Young Adult
%K Xanthines
%K Magnetic Resonance Imaging
%K A1AR (Other)
%K ASL (Other)
%K PET (Other)
%K [18F]CPFPX (Other)
%K adenosine receptors (Other)
%K hypoxia (Other)
%K Receptor, Adenosine A1 (NLM Chemicals)
%K Xanthines (NLM Chemicals)
%K 8-cyclopenta-3-(3-fluoropropyl)-1-propylxanthine (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:39667818
%R 10.2967/jnumed.124.268455
%U https://pub.dzne.de/record/274066