TY  - JOUR
AU  - Michno, Manuel
AU  - Schmitz, Jan
AU  - Foerges, Anna L
AU  - Beer, Simone
AU  - Jordan, Jens
AU  - Neumaier, Bernd
AU  - Drzezga, Alexander
AU  - Aeschbach, Daniel
AU  - Bauer, Andreas
AU  - Tank, Jens
AU  - Weis, Henning
AU  - Elmenhorst, Eva-Maria
AU  - Elmenhorst, David
TI  - Effect of Acute Hypoxia Exposure on the Availability of A1 Adenosine Receptors and Perfusion in the Human Brain.
JO  - Journal of nuclear medicine
VL  - 66
IS  - 1
SN  - 0097-9058
CY  - New York, NY
PB  - Soc.
M1  - DZNE-2025-00047
SP  - 142 - 149
PY  - 2025
AB  - In animal studies it has been observed that the inhibitory neuromodulator adenosine is released into the cerebral interstitial space during hypoxic challenges. Adenosine's actions on the A1 adenosine receptor (A1AR) protect the brain from oxygen deprivation and overexertion through adjustments in cerebral blood flow, metabolism, and electric activity. Methods: Using 8-cyclopentyl-3-(3-[18F]fluoropropyl)-1-propylxanthine ([18F]CPFPX), a PET tracer for the A1AR, we tested the hypothesis that hypoxia-induced adenosine release reduces A1AR availability in the human brain. Furthermore, we investigated whether this response is associated with altered brain perfusion and psychomotor vigilance. Ten healthy volunteers completed a 110-min bolus-plus-constant-infusion [18F]CPFPX PET/MRI hybrid experiment including a 30-min interval of normobaric hypoxia with peripheral oxygen saturation between 70
KW  - Humans
KW  - Male
KW  - Receptor, Adenosine A1: metabolism
KW  - Adult
KW  - Brain: diagnostic imaging
KW  - Brain: metabolism
KW  - Brain: blood supply
KW  - Female
KW  - Positron-Emission Tomography
KW  - Cerebrovascular Circulation
KW  - Hypoxia: metabolism
KW  - Hypoxia: physiopathology
KW  - Hypoxia: diagnostic imaging
KW  - Young Adult
KW  - Xanthines
KW  - Magnetic Resonance Imaging
KW  - A1AR (Other)
KW  - ASL (Other)
KW  - PET (Other)
KW  - [18F]CPFPX (Other)
KW  - adenosine receptors (Other)
KW  - hypoxia (Other)
KW  - Receptor, Adenosine A1 (NLM Chemicals)
KW  - Xanthines (NLM Chemicals)
KW  - 8-cyclopenta-3-(3-fluoropropyl)-1-propylxanthine (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:39667818
DO  - DOI:10.2967/jnumed.124.268455
UR  - https://pub.dzne.de/record/274066
ER  -