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@ARTICLE{Hakus:274068,
      author       = {Hakus, Aileen and Foo, Jerome Clifford and Casquero-Veiga,
                      Marta and Gül, Asude Zülal and Hintz, Franziska and
                      Rivalan, Marion and Winter, York and Priller, Josef and
                      Hadar, Ravit and Winter, Christine},
      title        = {{S}ex-associated differences in incentive salience and
                      drinking behaviour in a rodent model of alcohol relapse.},
      journal      = {Addiction biology},
      volume       = {30},
      number       = {1},
      issn         = {1355-6215},
      address      = {Hoboken, NJ [u.a.]},
      publisher    = {Wiley-Blackwell},
      reportid     = {DZNE-2025-00049},
      pages        = {e70009},
      year         = {2025},
      abstract     = {The ability of environmental cues to trigger
                      alcohol-seeking behaviours is thought to facilitate
                      problematic alcohol use. Individuals' tendency to attribute
                      incentive salience to cues may increase the risk of
                      addiction. We sought to study the relationship between
                      incentive salience and alcohol addiction using
                      non-preferring rats to model the heterogeneity of human
                      alcohol consumption, investigating both males and females.
                      Adult rats were subjected to the alcohol deprivation effect
                      (ADE) paradigm, where they were given voluntary access to
                      different alcohol solutions with repeated interruptions by
                      deprivation and reintroduction phases over a protracted
                      period (five Alcohol Deprivation Cycles). Before each
                      Alcohol Deprivation Cycle, rats were tested in the Pavlovian
                      Conditioned Approach (PCA) paradigm, which quantifies the
                      individual salience toward a conditional cue and the reward,
                      thus allowing us to trace the process of attributing
                      incentive salience to reward cues. During the final Alcohol
                      Deprivation Cycle (ADE5), animals were tested for
                      compulsive-like behaviour using quinine taste adulteration.
                      We investigated sex differences in drinking behaviour and
                      PCA performance. We observed thatb females drank
                      significantly more alcohol than males and displayed more
                      sign-tracking (ST) behaviour in the PCA, whereas males
                      showed goal-tracking (GT) behaviour. Furthermore, we found
                      that high drinkers exhibited more ST behaviour. The initial
                      PCA phenotype was correlated with later alcohol consumption.
                      Our findings indicate a complex relationship between
                      incentive salience and alcohol addiction and emphasize the
                      importance of considering both sexes in preclinical
                      research.},
      keywords     = {Animals / Male / Female / Rats / Motivation / Cues /
                      Conditioning, Classical: physiology / Alcoholism:
                      physiopathology / Disease Models, Animal / Alcohol Drinking:
                      psychology / Reward / Recurrence / Behavior, Animal / Sex
                      Factors / Sex Characteristics / Ethanol: pharmacology /
                      Pavlovian conditioned approach (Other) / alcohol addiction
                      (Other) / alcohol deprivation effect model (Other) / goal
                      tracker (Other) / incentive salience (Other) /
                      sign‐tracker (Other) / Ethanol (NLM Chemicals)},
      cin          = {AG Priller},
      ddc          = {540},
      cid          = {I:(DE-2719)5000007},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39764698},
      pmc          = {pmc:PMC11705499},
      doi          = {10.1111/adb.70009},
      url          = {https://pub.dzne.de/record/274068},
}