000274117 001__ 274117
000274117 005__ 20250523100558.0
000274117 0247_ $$2doi$$a10.1101/2024.12.17.24319143
000274117 0247_ $$2altmetric$$aaltmetric:172153078
000274117 037__ $$aDZNE-2025-00067
000274117 1001_ $$0P:(DE-2719)9001002$$aTalevi, Valentina$$b0$$eFirst author
000274117 245__ $$aAge and sex effects on blood retrotransposable element expression levels: Findings from the population-based Rhineland Study
000274117 260__ $$c2024
000274117 3367_ $$0PUB:(DE-HGF)25$$2PUB:(DE-HGF)$$aPreprint$$bpreprint$$mpreprint$$s1747916434_17480
000274117 3367_ $$2ORCID$$aWORKING_PAPER
000274117 3367_ $$028$$2EndNote$$aElectronic Article
000274117 3367_ $$2DRIVER$$apreprint
000274117 3367_ $$2BibTeX$$aARTICLE
000274117 3367_ $$2DataCite$$aOutput Types/Working Paper
000274117 520__ $$aRetrotransposable elements (RTEs) have been implicated in the pathogenesis of several age-associated diseases. Although model systems indicate that age- and sex-dependent loss of heterochromatin increases RTE expression, data from large human studies are lacking. Here we assessed the expression levels of 795 blood RTE subfamilies in 2467 participants of the population-based Rhineland Study. We found that the expression of more than 98% of RTE subfamilies increased with both chronological and biological age. Moreover, the expression of heterochromatin regulators involved in RTE silencing were negatively related to the expression of 690 RTE subfamilies. Finally, we observed sex differences in 42 RTE subfamilies, with higher expression in men. The genes mapped to sex-related RTEs were enriched in immune response-related pathways. Importantly, we validated our key findings in an independent population-based cohort. Our findings indicate that RTEs and their repressors are markers of aging, and that their dysregulation is linked to inflammation, especially in men.
000274117 536__ $$0G:(DE-HGF)POF4-354$$a354 - Disease Prevention and Healthy Aging (POF4-354)$$cPOF4-354$$fPOF IV$$x0
000274117 536__ $$0G:(DE-HGF)POF4-351$$a351 - Brain Function (POF4-351)$$cPOF4-351$$fPOF IV$$x1
000274117 536__ $$0G:(EU-Grant)101041677$$aTRANSIT-ND - Tandem Repeats Associated with Neurogenomic Somatic Instability and Neurodegeneration (101041677)$$c101041677$$fERC-2021-STG$$x2
000274117 588__ $$aDataset connected to CrossRef
000274117 693__ $$0EXP:(DE-2719)Rhineland Study-20190321$$5EXP:(DE-2719)Rhineland Study-20190321$$eRhineland Study / Bonn$$x0
000274117 7001_ $$0P:(DE-2719)2814197$$aLee, Hang-mao$$b1
000274117 7001_ $$0P:(DE-2719)2813521$$aLiu, Dan$$b2
000274117 7001_ $$0P:(DE-2719)2812219$$aBeyer, Marc$$b3
000274117 7001_ $$0P:(DE-2719)2811779$$aSalomoni, Paolo$$b4
000274117 7001_ $$0P:(DE-2719)2810403$$aBreteler, Monique$$b5
000274117 7001_ $$0P:(DE-2719)2812578$$aAziz, N. Ahmad$$b6$$eLast author
000274117 773__ $$a10.1101/2024.12.17.24319143
000274117 909CO $$ooai:pub.dzne.de:274117$$pec_fundedresources$$pVDB$$popenaire
000274117 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9001002$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b0$$kDZNE
000274117 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2814197$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b1$$kDZNE
000274117 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2813521$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b2$$kDZNE
000274117 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2812219$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b3$$kDZNE
000274117 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811779$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b4$$kDZNE
000274117 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2810403$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b5$$kDZNE
000274117 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2812578$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b6$$kDZNE
000274117 9131_ $$0G:(DE-HGF)POF4-354$$1G:(DE-HGF)POF4-350$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lNeurodegenerative Diseases$$vDisease Prevention and Healthy Aging$$x0
000274117 9131_ $$0G:(DE-HGF)POF4-351$$1G:(DE-HGF)POF4-350$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lNeurodegenerative Diseases$$vBrain Function$$x1
000274117 920__ $$lyes
000274117 9201_ $$0I:(DE-2719)5000071$$kAG Aziz$$lPopulation & Clinical Neuroepidemiology$$x0
000274117 9201_ $$0I:(DE-2719)1012001$$kAG Breteler$$lPopulation Health Sciences$$x1
000274117 9201_ $$0I:(DE-2719)1013032$$kAG Salomoni$$lNuclear Function in CNS Pathophysiology$$x2
000274117 9201_ $$0I:(DE-2719)1013035$$kAG Beyer$$lImmunogenomics and Neurodegeneration$$x3
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000274117 980__ $$aVDB
000274117 980__ $$aI:(DE-2719)5000071
000274117 980__ $$aI:(DE-2719)1012001
000274117 980__ $$aI:(DE-2719)1013032
000274117 980__ $$aI:(DE-2719)1013035
000274117 980__ $$aUNRESTRICTED