% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Fink:275833,
      author       = {Fink, Ryan and Imai, Shosei and Gockel, Nala and Lauer,
                      German and Renken, Kim and Wietek, Jonas and Lamothe-Molina,
                      Paul J and Furhmann, Falko and Mittag, Manuel and Ziebarth,
                      Tim and Canziani, Annika and Kubitschke, Martin and
                      Kistmacher, Vivien and Kretschmer, Anny and Sebastian, Eva
                      and Schmitz, Dietmar and Terai, Takuya and Gründemann, Jan
                      and Hassan, Sami and Patriarchi, Tommaso and Reiner, Andreas
                      and Fuhrmann, Martin and Campbell, Robert E and Masseck,
                      Olivia A},
      title        = {{P}inky{C}a{MP} a m{S}carlet-based calcium sensor with
                      exceptional brightness, photostability, and multiplexing
                      capabilities},
      journal      = {bioRxiv},
      reportid     = {DZNE-2025-00068},
      year         = {2024},
      abstract     = {Genetically encoded calcium (Ca2+) indicators (GECIs) are
                      widely used for imaging neuronal activity, yet current
                      limitations of existing red fluorescent GECIs have
                      constrained their applicability. The inherently dim
                      fluorescence and low signal-to-noise ratio of red-shifted
                      GECIs have posed significant challenges. More critically,
                      several red-fluorescent GECIs exhibit photoswitching when
                      exposed to blue light, thereby limiting their applicability
                      in all-optical experimental approaches. Here, we present the
                      development of PinkyCaMP, the first mScarlet-based Ca2+
                      sensor that outperforms current red fluorescent sensors in
                      brightness, photostability, signal-to-noise ratio, and
                      compatibility with optogenetics and neurotransmitter
                      imaging. PinkyCaMP is well-tolerated by neurons, showing no
                      toxicity or aggregation, both in vitro and in vivo. All
                      imaging approaches, including single-photon excitation
                      methods such as fiber photometry, widefield imaging,
                      miniscope imaging, as well as two-photon imaging in awake
                      mice, are fully compatible with PinkyCaMP.},
      cin          = {AG Gründemann / AG Fuhrmann / AG Schmitz},
      cid          = {I:(DE-2719)5000069 / I:(DE-2719)1011004 /
                      I:(DE-2719)1810004},
      pnm          = {351 - Brain Function (POF4-351)},
      pid          = {G:(DE-HGF)POF4-351},
      typ          = {PUB:(DE-HGF)25},
      pubmed       = {pmid:39763884},
      doi          = {10.1101/2024.12.16.628673},
      url          = {https://pub.dzne.de/record/275833},
}