TY  - JOUR
AU  - Hille, Maike
AU  - Kühn, Simone
AU  - Kempermann, Gerd
AU  - Bonhoeffer, Tobias
AU  - Lindenberger, Ulman
TI  - From animal models to human individuality: Integrative approaches to the study of brain plasticity.
JO  - Neuron
VL  - 112
IS  - 21
SN  - 0896-6273
CY  - [Cambridge, Mass.]
PB  - Cell Press
M1  - DZNE-2025-00078
SP  - 3522 - 3541
PY  - 2024
AB  - Plasticity allows organisms to form lasting adaptive changes in neural structures in response to interactions with the environment. It serves both species-general functions and individualized skill acquisition. To better understand human plasticity, we need to strengthen the dialogue between human research and animal models. Therefore, we propose to (1) enhance the interpretability of macroscopic methods used in human research by complementing molecular and fine-structural measures used in animals with such macroscopic methods, preferably applied to the same animals, to create macroscopic metrics common to both examined species; (2) launch dedicated cross-species research programs, using either well-controlled experimental paradigms, such as motor skill acquisition, or more naturalistic environments, where individuals of either species are observed in their habitats; and (3) develop conceptual and computational models linking molecular and fine-structural events to phenomena accessible by macroscopic methods. In concert, these three component strategies can foster new insights into the nature of plastic change.
KW  - Animals
KW  - Humans
KW  - Neuronal Plasticity: physiology
KW  - Brain: physiology
KW  - Models, Animal
KW  - Individuality
KW  - animal models (Other)
KW  - brain plasticity (Other)
KW  - cross-level integration (Other)
KW  - enrichment (Other)
KW  - individuality (Other)
KW  - skill acquisition (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:39461332
DO  - DOI:10.1016/j.neuron.2024.10.006
UR  - https://pub.dzne.de/record/275843
ER  -