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@ARTICLE{Hille:275843,
author = {Hille, Maike and Kühn, Simone and Kempermann, Gerd and
Bonhoeffer, Tobias and Lindenberger, Ulman},
title = {{F}rom animal models to human individuality: {I}ntegrative
approaches to the study of brain plasticity.},
journal = {Neuron},
volume = {112},
number = {21},
issn = {0896-6273},
address = {[Cambridge, Mass.]},
publisher = {Cell Press},
reportid = {DZNE-2025-00078},
pages = {3522 - 3541},
year = {2024},
abstract = {Plasticity allows organisms to form lasting adaptive
changes in neural structures in response to interactions
with the environment. It serves both species-general
functions and individualized skill acquisition. To better
understand human plasticity, we need to strengthen the
dialogue between human research and animal models.
Therefore, we propose to (1) enhance the interpretability of
macroscopic methods used in human research by complementing
molecular and fine-structural measures used in animals with
such macroscopic methods, preferably applied to the same
animals, to create macroscopic metrics common to both
examined species; (2) launch dedicated cross-species
research programs, using either well-controlled experimental
paradigms, such as motor skill acquisition, or more
naturalistic environments, where individuals of either
species are observed in their habitats; and (3) develop
conceptual and computational models linking molecular and
fine-structural events to phenomena accessible by
macroscopic methods. In concert, these three component
strategies can foster new insights into the nature of
plastic change.},
subtyp = {Review Article},
keywords = {Animals / Humans / Neuronal Plasticity: physiology / Brain:
physiology / Models, Animal / Individuality / animal models
(Other) / brain plasticity (Other) / cross-level integration
(Other) / enrichment (Other) / individuality (Other) / skill
acquisition (Other)},
cin = {AG Kempermann},
ddc = {610},
cid = {I:(DE-2719)1710001},
pnm = {352 - Disease Mechanisms (POF4-352)},
pid = {G:(DE-HGF)POF4-352},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:39461332},
doi = {10.1016/j.neuron.2024.10.006},
url = {https://pub.dzne.de/record/275843},
}