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000275850 0247_ $$2ISSN$$a0367-004X
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000275850 0247_ $$2ISSN$$a0340-5354
000275850 0247_ $$2ISSN$$a1432-1459
000275850 037__ $$aDZNE-2025-00085
000275850 041__ $$aEnglish
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000275850 1001_ $$0P:(DE-2719)9003372$$aHopfner, Franziska$$b0$$udzne
000275850 245__ $$aDefinition and diagnosis of Parkinson's disease: guideline 'Parkinson's disease' of the German Society of Neurology.
000275850 260__ $$a[Darmstadt]$$bSteinkopff$$c2024
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000275850 520__ $$aAccurate definition and operational criteria for diagnosing Parkinson's disease (PD) are crucial for evidence-based, patient-centered care.To offer evidence-based recommendations for defining and diagnosing PD, incorporating contemporary clinical, imaging, biomarker, and genetic insights.The guideline development began with the steering committee establishing key PICO (patient, intervention, comparison, outcome) questions, which were refined by the coauthors. Systematic literature searches identified relevant studies, reviews, and meta-analyses. Recommendations were drafted, evaluated, optimized, and voted upon by the German Parkinson's Guideline Group.Parkinson's disease (PD) is now understood to encompass a broader spectrum of etiologies than previously recognized. Advances in molecular pathogenesis, neuroimaging, and early clinical phenotypes suggest that PD is not a uniform disease entity and is often not idiopathic. This necessitates an updated framework for PD definition and diagnosis. The German Society for Neurology now endorses a broader concept of PD, incorporating both idiopathic and hereditary forms, as opposed to the previously narrower concept of 'idiopathic Parkinson syndrome.' The revised guidelines recommend using the 2015 Movement Disorders Society diagnostic criteria, emphasize the importance of long-term clinical follow-up for improved diagnostic accuracy, and highlight the significance of non-motor symptoms in clinical diagnosis. Specific recommendations are provided for the use of imaging and fluid biomarkers and genetic testing to support the clinical diagnosis.The updated guidelines from the German Society for Neurology enhance diagnostic accuracy for PD, promoting optimized clinical care.
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000275850 650_7 $$2Other$$aBiomarkers
000275850 650_7 $$2Other$$aDefinition
000275850 650_7 $$2Other$$aDiagnosis
000275850 650_7 $$2Other$$aGenetics
000275850 650_7 $$2Other$$aImaging
000275850 650_7 $$2Other$$aParkinson’s disease
000275850 650_2 $$2MeSH$$aHumans
000275850 650_2 $$2MeSH$$aGermany
000275850 650_2 $$2MeSH$$aNeurology: standards
000275850 650_2 $$2MeSH$$aParkinson Disease: diagnosis
000275850 650_2 $$2MeSH$$aPractice Guidelines as Topic: standards
000275850 650_2 $$2MeSH$$aSocieties, Medical: standards
000275850 650_2 $$2MeSH$$aSystematic Reviews as Topic
000275850 7001_ $$0P:(DE-2719)2811373$$aHöglinger, Günter$$b1$$udzne
000275850 7001_ $$aGroup, German Parkinson’s Guidelines$$b2$$eCollaboration Author
000275850 7001_ $$aTrenkwalder, Claudia$$b3
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