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| 001 | 275859 | ||
| 005 | 20250113165814.0 | ||
| 024 | 7 | _ | |a 10.1016/j.nsa.2024.104075 |2 doi |
| 037 | _ | _ | |a DZNE-2025-00094 |
| 100 | 1 | _ | |a Garrett, Lillian |b 0 |
| 245 | _ | _ | |a Co-expression of prepulse inhibition and Schizophrenia genes in the mouse and human brain |
| 260 | _ | _ | |a Amsterdam |c 2024 |b Elsevier |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1736773887_1045 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Schizophrenia is a complex psychiatric disorder with genetic and phenotypic heterogeneity. Accumulating rare and genome-wide association study (GWAS) common risk variant information has yet to yield robust mechanistic insight. Leveraging large-scale gene deletion mouse phenomic data thus has potential to functionally interrogate and prioritize human disease genes. To this end, we applied a cross-species network-based approach to parse an extensive mouse gene set (188 genes) associated with disrupted prepulse inhibition (PPI), a Schizophrenia endophenotype. Integrating PPI genes with high-resolution mouse and human brain transcriptomic data, we identified functional and disease coherent co-expression modules through hierarchical clustering and weighted gene co-expression network analysis (WGCNA). In two modules, Schizophrenia risk and mouse PPI genes converged based on telencephalic patterning. The associated neuronal genes were highly expressed in cingulate cortex and hippocampus; implicated in synaptic function and neurotransmission and overlapped with the greatest proportion of rare variants. Concordant neuroanatomical patterning revealed novel core Schizophrenia-relevant genes consistent with the Omnigenic hypothesis of complex traits. Among other genes discussed, the developmental and post-synaptic scaffold TANC2 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2) emerged from both networks as a novel core genetic driver of Schizophrenia altering PPI. Aspects of psychiatric disease comorbidity and phenotypic heterogeneity are also explored. Overall, this study provides a framework and galvanizes the value of mouse preclinical genetics and PPI to prioritize both existing and novel human Schizophrenia candidate genes as druggable targets. |
| 536 | _ | _ | |a 352 - Disease Mechanisms (POF4-352) |0 G:(DE-HGF)POF4-352 |c POF4-352 |f POF IV |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, Journals: pub.dzne.de |
| 700 | 1 | _ | |a Trumbach, Dietrich |0 P:(DE-2719)9000367 |b 1 |
| 700 | 1 | _ | |a Lee, Donghyung |b 2 |
| 700 | 1 | _ | |a Mandillo, Silvia |0 0000-0002-4869-0974 |b 3 |
| 700 | 1 | _ | |a Samaco, Rodney |0 0000-0001-5636-5314 |b 4 |
| 700 | 1 | _ | |a Flenniken, Ann M. |b 5 |
| 700 | 1 | _ | |a Stewart, Michelle |b 6 |
| 700 | 1 | _ | |a Aguilar-Pimental, Juan A. |b 7 |
| 700 | 1 | _ | |a Amarie, Oana V. |b 8 |
| 700 | 1 | _ | |a Becker, Lore |b 9 |
| 700 | 1 | _ | |a Calzada-Wack, Julia |b 10 |
| 700 | 1 | _ | |a Da Silva-Buttkus, Patricia |b 11 |
| 700 | 1 | _ | |a Dragano, Nathalia |b 12 |
| 700 | 1 | _ | |a Kraiger, Markus |b 13 |
| 700 | 1 | _ | |a Lengger, Christoph |b 14 |
| 700 | 1 | _ | |a Leuchtenberger, Stefanie |b 15 |
| 700 | 1 | _ | |a Marschall, Susan |b 16 |
| 700 | 1 | _ | |a Oestereicher, Manuela A. |b 17 |
| 700 | 1 | _ | |a Rathkolb, Birgit |b 18 |
| 700 | 1 | _ | |a Sanz-Moreno, Adrián |b 19 |
| 700 | 1 | _ | |a Seisenberger, Claudia |b 20 |
| 700 | 1 | _ | |a Spielmann, Nadine |b 21 |
| 700 | 1 | _ | |a Stoeger, Claudia |b 22 |
| 700 | 1 | _ | |a Kumar, Vivek |b 23 |
| 700 | 1 | _ | |a Keskivali, Piia |b 24 |
| 700 | 1 | _ | |a King, Ruairidh |b 25 |
| 700 | 1 | _ | |a Haselimashhadi, Hamed |b 26 |
| 700 | 1 | _ | |a Bezginov, Alexandr |b 27 |
| 700 | 1 | _ | |a Norris, Clare |b 28 |
| 700 | 1 | _ | |a Taylor, Sarah |b 29 |
| 700 | 1 | _ | |a Pimm, Dale |b 30 |
| 700 | 1 | _ | |a Kelsey, Lois |b 31 |
| 700 | 1 | _ | |a Berberovic, Zorana |b 32 |
| 700 | 1 | _ | |a Qu, Dawei |b 33 |
| 700 | 1 | _ | |a D'Souza, Abigail |b 34 |
| 700 | 1 | _ | |a Bradaschia, Vivian |b 35 |
| 700 | 1 | _ | |a Eskandarian, Mohammed |b 36 |
| 700 | 1 | _ | |a Shang, Xueyuan |b 37 |
| 700 | 1 | _ | |a Duffin, Kyle |b 38 |
| 700 | 1 | _ | |a Roberton, Kyle |b 39 |
| 700 | 1 | _ | |a Xu, Catherine |b 40 |
| 700 | 1 | _ | |a Baguinat, Gloria |b 41 |
| 700 | 1 | _ | |a Laurin, Valerie |b 42 |
| 700 | 1 | _ | |a Lan, Qing |b 43 |
| 700 | 1 | _ | |a Sleep, Gillian |b 44 |
| 700 | 1 | _ | |a Lintott, Lauri |b 45 |
| 700 | 1 | _ | |a Gertsenstein, Marina |b 46 |
| 700 | 1 | _ | |a Tondat, Sandra |b 47 |
| 700 | 1 | _ | |a Cruz, Maribelle |b 48 |
| 700 | 1 | _ | |a Miller, David |b 49 |
| 700 | 1 | _ | |a Bezginov, Alexandr |b 50 |
| 700 | 1 | _ | |a Sorg, Tania |b 51 |
| 700 | 1 | _ | |a Riet, Fabrice |b 52 |
| 700 | 1 | _ | |a Tolentino, Heather |b 53 |
| 700 | 1 | _ | |a Tolentino, Todd |b 54 |
| 700 | 1 | _ | |a Schuchbauer, Mike |b 55 |
| 700 | 1 | _ | |a Hockenbury, Nichole |b 56 |
| 700 | 1 | _ | |a Beeman, Karrie |b 57 |
| 700 | 1 | _ | |a Pedroia, Sheryl |b 58 |
| 700 | 1 | _ | |a Salazar, Jason |b 59 |
| 700 | 1 | _ | |a Heffner, Mollie |b 60 |
| 700 | 1 | _ | |a Hsu, Joanne |b 61 |
| 700 | 1 | _ | |a Fletcher, Colin |b 62 |
| 700 | 1 | _ | |a Vanzanten, Maya |b 63 |
| 700 | 1 | _ | |a Golini, Elisabetta |b 64 |
| 700 | 1 | _ | |a Seavitt, John R. |b 65 |
| 700 | 1 | _ | |a Lanza, Denise G. |b 66 |
| 700 | 1 | _ | |a Lorenzo, Isabel |b 67 |
| 700 | 1 | _ | |a Gaspero, Angelina |b 68 |
| 700 | 1 | _ | |a Rios, Amanda |b 69 |
| 700 | 1 | _ | |a White, Jacqueline K. |b 70 |
| 700 | 1 | _ | |a McKerlie, Colin |b 71 |
| 700 | 1 | _ | |a Nutter, Lauryl M. J. |0 0000-0001-9619-146X |b 72 |
| 700 | 1 | _ | |a Vukobradovic, Igor |b 73 |
| 700 | 1 | _ | |a Veeraragavan, Surabi |b 74 |
| 700 | 1 | _ | |a Yuva, Lisa |b 75 |
| 700 | 1 | _ | |a Heaney, Jason D. |b 76 |
| 700 | 1 | _ | |a Dickinson, Mary E. |b 77 |
| 700 | 1 | _ | |a Meziane, Hamid |0 0000-0002-4704-7055 |b 78 |
| 700 | 1 | _ | |a Hérault, Yann |0 0000-0001-7049-6900 |b 79 |
| 700 | 1 | _ | |a Wells, Sara |0 0000-0002-0572-0600 |b 80 |
| 700 | 1 | _ | |a Lloyd, K. C. Kent |0 0000-0002-5318-4144 |b 81 |
| 700 | 1 | _ | |a Bower, Lynette |b 82 |
| 700 | 1 | _ | |a Lanoue, Louise |b 83 |
| 700 | 1 | _ | |a Clary, Dave |0 0000-0002-3315-7333 |b 84 |
| 700 | 1 | _ | |a Zimprich, Annemarie |0 0000-0003-2078-6779 |b 85 |
| 700 | 1 | _ | |a Gailus-Durner, Valerie |b 86 |
| 700 | 1 | _ | |a Fuchs, Helmut |b 87 |
| 700 | 1 | _ | |a Brown, Steve D. M. |b 88 |
| 700 | 1 | _ | |a Chesler, Elissa J. |0 0000-0002-5642-5062 |b 89 |
| 700 | 1 | _ | |a Wurst, Wolfgang |0 P:(DE-2719)2000028 |b 90 |u dzne |
| 700 | 1 | _ | |a Hrabě de Angelis, Martin |b 91 |
| 700 | 1 | _ | |a Hölter, Sabine M. |b 92 |
| 773 | _ | _ | |a 10.1016/j.nsa.2024.104075 |g Vol. 3, p. 104075 - |0 PERI:(DE-600)3154568-3 |p 104075 |t Neuroscience Applied |v 3 |y 2024 |x 2772-4085 |
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