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000275862 1001_ $$aSalazar Campos, José María$$b0
000275862 245__ $$aAre oligodendrocytes bystanders or drivers of Parkinson's disease pathology?
000275862 260__ $$aLawrence, KS$$bPLoS$$c2025
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000275862 520__ $$aThe major pathological feature of Parkinson 's disease (PD), the second most common neurodegenerative disease and most common movement disorder, is the predominant degeneration of dopaminergic neurons in the substantia nigra, a part of the midbrain. Despite decades of research, the molecular mechanisms of the origin of the disease remain unknown. While the disease was initially viewed as a purely neuronal disorder, results from single-cell transcriptomics have suggested that oligodendrocytes may play an important role in the early stages of Parkinson's. Although these findings are of high relevance, particularly to the search for effective disease-modifying therapies, the actual functional role of oligodendrocytes in Parkinson's disease remains highly speculative and requires a concerted scientific effort to be better understood. This Unsolved Mystery discusses the limited understanding of oligodendrocytes in PD, highlighting unresolved questions regarding functional changes in oligodendroglia, the role of myelin in nigral dopaminergic neurons, the impact of the toxic environment, and the aggregation of alpha-synuclein within oligodendrocytes.
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000275862 650_7 $$2NLM Chemicals$$aalpha-Synuclein
000275862 650_2 $$2MeSH$$aOligodendroglia: metabolism
000275862 650_2 $$2MeSH$$aOligodendroglia: pathology
000275862 650_2 $$2MeSH$$aParkinson Disease: pathology
000275862 650_2 $$2MeSH$$aParkinson Disease: metabolism
000275862 650_2 $$2MeSH$$aParkinson Disease: genetics
000275862 650_2 $$2MeSH$$aHumans
000275862 650_2 $$2MeSH$$aalpha-Synuclein: metabolism
000275862 650_2 $$2MeSH$$aDopaminergic Neurons: metabolism
000275862 650_2 $$2MeSH$$aDopaminergic Neurons: pathology
000275862 650_2 $$2MeSH$$aSubstantia Nigra: metabolism
000275862 650_2 $$2MeSH$$aSubstantia Nigra: pathology
000275862 650_2 $$2MeSH$$aAnimals
000275862 650_2 $$2MeSH$$aMyelin Sheath: metabolism
000275862 650_2 $$2MeSH$$aMyelin Sheath: pathology
000275862 7001_ $$0P:(DE-2719)9000040$$aBurbulla, Lena F$$b1$$udzne
000275862 7001_ $$00000-0002-9634-2472$$aJäkel, Sarah$$b2
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