TY  - JOUR
AU  - Ramadan, Dana
AU  - Mueller, Sebastian
AU  - Stirnberg, Rüdiger
AU  - Bosch, Dario
AU  - Ehses, Philipp
AU  - Scheffler, Klaus
AU  - Bause, Jonas
TI  - Macrovascular contributions to resting-state fMRI signals: A comparison between EPI and bSSFP at 9.4 Tesla
JO  - Imaging neuroscience
VL  - 3
SN  - 2837-6056
CY  - Cambridge, MA
PB  - MIT Press
M1  - DZNE-2025-00098
SP  - imag_a_00435
PY  - 2025
AB  -  The draining-vein bias of T2*-weighted sequences, like gradient echo echo-planar imaging (GRE-EPI), can limit the spatial specificity of functional MRI (fMRI). The underlying extravascular signal changes increase with field strength (B0) and the perpendicularity of draining veins to the main axis of B0, and are, therefore, particularly problematic at ultra-high field (UHF). In contrast, simulations showed that T2-weighted sequences are less affected by the draining-vein bias, depending on the amount of rephasing of extravascular signal. As large pial veins on the cortical surface follow the cortical folding tightly, their orientation can be approximated by the cortical orientation to B 0 → . In our work, we compare the influence of the cortical orientation to B 0 → on the resting-state fMRI signal of three sequences aiming to understand their macrovascular contribution. While 2D GRE-EPI and 3D GRE-EPI (both T2*-weighted) showed a high dependence on the cortical orientation to B 0 → , especially on the cortical surface, this was not the case for 3D balanced steady-state free precession (bSSFP) (T2/T1-weighted). Here, a slight increase of orientation dependence was shown in depths closest to white matter (WM). And while orientation dependence decreased with increased distance to the veins for both EPI sequences, no change in orientation dependence was observed in bSSFP. This indicates the low macrovascular contribution to the bSSFP signal, making it a promising sequence for layer fMRI at UHF.
LB  - PUB:(DE-HGF)16
C6  - pmid:40800877
C2  - pmc:PMC12320002
DO  - DOI:10.1162/imag_a_00435
UR  - https://pub.dzne.de/record/275863
ER  -