%0 Journal Article
%A Liu, Kathy Y
%A Betts, Matthew J
%A Hämmerer, Dorothea
%A Düzel, Emrah
%A Mather, Mara
%A Roiser, Jonathan P
%A Schneider, Anja
%A Spottke, Annika
%A Rostamzadeh, Ayda
%A Schott, Björn H
%A Rauchmann, Boris Stephan
%A Laske, Christoph
%A Janowitz, Daniel
%A Spruth, Eike Jakob
%A Ersözlü, Ersin
%A Lüsebrink, Falk
%A Jessen, Frank
%A Frommann, Ingo
%A Kilimann, Ingo
%A Wiltfang, Jens
%A Brustkern, Johanna
%A Priller, Josef
%A Hellmann-Regen, Julian David Nicolai
%A Buerger, Katharina
%A Fliessbach, Klaus
%A Scheffler, Klaus
%A Kleineidam, Luca
%A Stark, Melina
%A Ewers, Michael
%A Wagner, Michael
%A Peters, Oliver
%A Dechent, Peter
%A Perneczky, Robert
%A Sodenkamp, Sebastian
%A Hetzer, Stefan
%A Teipel, Stefan
%A Glanz, Wenzel
%A Howard, Robert
%T Locus coeruleus signal intensity and emotion regulation in agitation in Alzheimer's disease.
%J Brain communications
%V 7
%N 1
%@ 2632-1297
%C [Oxford]
%I Oxford University Press
%M DZNE-2025-00099
%P fcae457
%D 2025
%X Hyperphosphorylated tau accumulation is seen in the noradrenergic locus coeruleus from the earliest stages of Alzheimer's disease onwards and has been associated with symptoms of agitation. It is hypothesized that compensatory locus coeruleus-noradrenaline system overactivity and impaired emotion regulation could underlie agitation propensity, but to our knowledge this has not previously been investigated. A better understanding of the neurobiological underpinnings of agitation would help the development of targeted prevention and treatment strategies. Using a sample of individuals with amnestic mild cognitive impairment and probable mild Alzheimer's disease dementia from the German Center for Neurodegenerative Diseases (DZNE)-Longitudinal Cognitive Impairment and Dementia (DELCODE) study cohort (N = 309, aged 67-96 years, 51
%K Alzheimer (Other)
%K agitation (Other)
%K autonomic (Other)
%K emotion regulation (Other)
%K locus coeruleus (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:39801712
%2 pmc:PMC11724426
%R 10.1093/braincomms/fcae457
%U https://pub.dzne.de/record/275864