TY  - JOUR
AU  - Liu, Kathy Y
AU  - Betts, Matthew J
AU  - Hämmerer, Dorothea
AU  - Düzel, Emrah
AU  - Mather, Mara
AU  - Roiser, Jonathan P
AU  - Schneider, Anja
AU  - Spottke, Annika
AU  - Rostamzadeh, Ayda
AU  - Schott, Björn H
AU  - Rauchmann, Boris Stephan
AU  - Laske, Christoph
AU  - Janowitz, Daniel
AU  - Spruth, Eike Jakob
AU  - Ersözlü, Ersin
AU  - Lüsebrink, Falk
AU  - Jessen, Frank
AU  - Frommann, Ingo
AU  - Kilimann, Ingo
AU  - Wiltfang, Jens
AU  - Brustkern, Johanna
AU  - Priller, Josef
AU  - Hellmann-Regen, Julian David Nicolai
AU  - Buerger, Katharina
AU  - Fliessbach, Klaus
AU  - Scheffler, Klaus
AU  - Kleineidam, Luca
AU  - Stark, Melina
AU  - Ewers, Michael
AU  - Wagner, Michael
AU  - Peters, Oliver
AU  - Dechent, Peter
AU  - Perneczky, Robert
AU  - Sodenkamp, Sebastian
AU  - Hetzer, Stefan
AU  - Teipel, Stefan
AU  - Glanz, Wenzel
AU  - Howard, Robert
TI  - Locus coeruleus signal intensity and emotion regulation in agitation in Alzheimer's disease.
JO  - Brain communications
VL  - 7
IS  - 1
SN  - 2632-1297
CY  - [Oxford]
PB  - Oxford University Press
M1  - DZNE-2025-00099
SP  - fcae457
PY  - 2025
AB  - Hyperphosphorylated tau accumulation is seen in the noradrenergic locus coeruleus from the earliest stages of Alzheimer's disease onwards and has been associated with symptoms of agitation. It is hypothesized that compensatory locus coeruleus-noradrenaline system overactivity and impaired emotion regulation could underlie agitation propensity, but to our knowledge this has not previously been investigated. A better understanding of the neurobiological underpinnings of agitation would help the development of targeted prevention and treatment strategies. Using a sample of individuals with amnestic mild cognitive impairment and probable mild Alzheimer's disease dementia from the German Center for Neurodegenerative Diseases (DZNE)-Longitudinal Cognitive Impairment and Dementia (DELCODE) study cohort (N = 309, aged 67-96 years, 51
KW  - Alzheimer (Other)
KW  - agitation (Other)
KW  - autonomic (Other)
KW  - emotion regulation (Other)
KW  - locus coeruleus (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:39801712
C2  - pmc:PMC11724426
DO  - DOI:10.1093/braincomms/fcae457
UR  - https://pub.dzne.de/record/275864
ER  -