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000275877 041__ $$aEnglish
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000275877 1001_ $$0P:(DE-2719)9002589$$aGroh, Janos$$b0$$eFirst author$$udzne
000275877 245__ $$aWhite matter aging and its impact on brain function.
000275877 260__ $$a[Cambridge, Mass.]$$bCell Press$$c2025
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000275877 520__ $$aAging has a detrimental impact on white matter, resulting in reduced volume, compromised structural integrity of myelinated axons, and an increase in white matter hyperintensities. These changes are closely linked to cognitive decline and neurological disabilities. The deterioration of myelin and its diminished ability to regenerate as we age further contribute to the progression of neurodegenerative disorders. Understanding these changes is crucial for devising effective disease prevention strategies. Here, we will discuss the structural alterations in white matter that occur with aging and examine the cellular and molecular mechanisms driving these aging-related transformations. We highlight how the progressive disruption of white matter may initiate a self-perpetuating cycle of inflammation and neural damage.
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000275877 650_7 $$2Other$$aaging
000275877 650_7 $$2Other$$amyelin
000275877 650_7 $$2Other$$aneuroinflammation
000275877 650_7 $$2Other$$awhite matter
000275877 650_2 $$2MeSH$$aHumans
000275877 650_2 $$2MeSH$$aWhite Matter: pathology
000275877 650_2 $$2MeSH$$aAging: physiology
000275877 650_2 $$2MeSH$$aBrain: physiology
000275877 650_2 $$2MeSH$$aAnimals
000275877 650_2 $$2MeSH$$aMyelin Sheath: physiology
000275877 7001_ $$0P:(DE-2719)2811642$$aSimons, Mikael$$b1$$eLast author$$udzne
000275877 773__ $$0PERI:(DE-600)2001944-0$$a10.1016/j.neuron.2024.10.019$$gVol. 113, no. 1, p. 127 - 139$$n1$$p127 - 139$$tNeuron$$v113$$x0896-6273$$y2025
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