TY  - JOUR
AU  - Groh, Janos
AU  - Simons, Mikael
TI  - White matter aging and its impact on brain function.
JO  - Neuron
VL  - 113
IS  - 1
SN  - 0896-6273
CY  - [Cambridge, Mass.]
PB  - Cell Press
M1  - DZNE-2025-00112
SP  - 127 - 139
PY  - 2025
AB  - Aging has a detrimental impact on white matter, resulting in reduced volume, compromised structural integrity of myelinated axons, and an increase in white matter hyperintensities. These changes are closely linked to cognitive decline and neurological disabilities. The deterioration of myelin and its diminished ability to regenerate as we age further contribute to the progression of neurodegenerative disorders. Understanding these changes is crucial for devising effective disease prevention strategies. Here, we will discuss the structural alterations in white matter that occur with aging and examine the cellular and molecular mechanisms driving these aging-related transformations. We highlight how the progressive disruption of white matter may initiate a self-perpetuating cycle of inflammation and neural damage.
KW  - Humans
KW  - White Matter: pathology
KW  - Aging: physiology
KW  - Brain: physiology
KW  - Animals
KW  - Myelin Sheath: physiology
KW  - aging (Other)
KW  - myelin (Other)
KW  - neuroinflammation (Other)
KW  - white matter (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:39541972
DO  - DOI:10.1016/j.neuron.2024.10.019
UR  - https://pub.dzne.de/record/275877
ER  -