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@ARTICLE{Groh:275877,
      author       = {Groh, Janos and Simons, Mikael},
      title        = {{W}hite matter aging and its impact on brain function.},
      journal      = {Neuron},
      volume       = {113},
      number       = {1},
      issn         = {0896-6273},
      address      = {[Cambridge, Mass.]},
      publisher    = {Cell Press},
      reportid     = {DZNE-2025-00112},
      pages        = {127 - 139},
      year         = {2025},
      abstract     = {Aging has a detrimental impact on white matter, resulting
                      in reduced volume, compromised structural integrity of
                      myelinated axons, and an increase in white matter
                      hyperintensities. These changes are closely linked to
                      cognitive decline and neurological disabilities. The
                      deterioration of myelin and its diminished ability to
                      regenerate as we age further contribute to the progression
                      of neurodegenerative disorders. Understanding these changes
                      is crucial for devising effective disease prevention
                      strategies. Here, we will discuss the structural alterations
                      in white matter that occur with aging and examine the
                      cellular and molecular mechanisms driving these
                      aging-related transformations. We highlight how the
                      progressive disruption of white matter may initiate a
                      self-perpetuating cycle of inflammation and neural damage.},
      subtyp        = {Review Article},
      keywords     = {Humans / White Matter: pathology / Aging: physiology /
                      Brain: physiology / Animals / Myelin Sheath: physiology /
                      aging (Other) / myelin (Other) / neuroinflammation (Other) /
                      white matter (Other)},
      cin          = {AG Simons},
      ddc          = {610},
      cid          = {I:(DE-2719)1110008},
      pnm          = {351 - Brain Function (POF4-351)},
      pid          = {G:(DE-HGF)POF4-351},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39541972},
      doi          = {10.1016/j.neuron.2024.10.019},
      url          = {https://pub.dzne.de/record/275877},
}