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001     275877
005     20250126000508.0
024 7 _ |a 10.1016/j.neuron.2024.10.019
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024 7 _ |a 0896-6273
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024 7 _ |a 1097-4199
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037 _ _ |a DZNE-2025-00112
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082 _ _ |a 610
100 1 _ |a Groh, Janos
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245 _ _ |a White matter aging and its impact on brain function.
260 _ _ |a [Cambridge, Mass.]
|c 2025
|b Cell Press
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520 _ _ |a Aging has a detrimental impact on white matter, resulting in reduced volume, compromised structural integrity of myelinated axons, and an increase in white matter hyperintensities. These changes are closely linked to cognitive decline and neurological disabilities. The deterioration of myelin and its diminished ability to regenerate as we age further contribute to the progression of neurodegenerative disorders. Understanding these changes is crucial for devising effective disease prevention strategies. Here, we will discuss the structural alterations in white matter that occur with aging and examine the cellular and molecular mechanisms driving these aging-related transformations. We highlight how the progressive disruption of white matter may initiate a self-perpetuating cycle of inflammation and neural damage.
536 _ _ |a 351 - Brain Function (POF4-351)
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650 _ 7 |a aging
|2 Other
650 _ 7 |a myelin
|2 Other
650 _ 7 |a neuroinflammation
|2 Other
650 _ 7 |a white matter
|2 Other
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a White Matter: pathology
|2 MeSH
650 _ 2 |a Aging: physiology
|2 MeSH
650 _ 2 |a Brain: physiology
|2 MeSH
650 _ 2 |a Animals
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650 _ 2 |a Myelin Sheath: physiology
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700 1 _ |a Simons, Mikael
|0 P:(DE-2719)2811642
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773 _ _ |a 10.1016/j.neuron.2024.10.019
|g Vol. 113, no. 1, p. 127 - 139
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|t Neuron
|v 113
|y 2025
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856 4 _ |y OpenAccess
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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