% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Barde:275879,
      author       = {Barde, Warsha and Renner, Jonas and Emery, Brett and
                      Khanzada, Shahrukh and Hu, Xin and Garthe, Alexander and
                      Rünker, Annette E and Amin, Hayder and Kempermann, Gerd},
      title        = {{B}eyond nature, nurture, and chance: {I}ndividual agency
                      shapes divergent learning biographies and brain connectome.},
      journal      = {Science advances},
      volume       = {11},
      number       = {2},
      issn         = {2375-2548},
      address      = {Washington, DC [u.a.]},
      publisher    = {Assoc.},
      reportid     = {DZNE-2025-00114},
      pages        = {eads7297},
      year         = {2025},
      abstract     = {Individual choices shape life course trajectories of brain
                      structure and function beyond genes and environment. We
                      hypothesized that individual task engagement in response to
                      a learning program results in individualized learning
                      biographies and connectomics. Genetically identical female
                      mice living in one large shared enclosure freely engaged in
                      self-paced, automatically administered and monitored
                      learning tasks. We discovered growing and increasingly
                      stable interindividual differences in learning trajectories.
                      Adult hippocampal neurogenesis and connectivity as assessed
                      by a high-density multielectrode array positively correlated
                      with the variation in exploration and learning efficiency.
                      During some tasks, divergence transiently collapsed,
                      highlighting the sustained significance of context for
                      individualization. Thus, equal environments and equal genes
                      do not result in equal learning biographies because life
                      confronts individuals with choices that lead to divergent
                      paths.},
      keywords     = {Animals / Connectome / Mice / Female / Learning: physiology
                      / Brain: physiology / Brain: diagnostic imaging /
                      Hippocampus: physiology / Neurogenesis},
      cin          = {AG Kempermann / AG Amin / AG Garthe},
      ddc          = {500},
      cid          = {I:(DE-2719)1710001 / I:(DE-2719)1710010 /
                      I:(DE-2719)1740001},
      pnm          = {352 - Disease Mechanisms (POF4-352) / 351 - Brain Function
                      (POF4-351)},
      pid          = {G:(DE-HGF)POF4-352 / G:(DE-HGF)POF4-351},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39792659},
      pmc          = {pmc:PMC11721517},
      doi          = {10.1126/sciadv.ads7297},
      url          = {https://pub.dzne.de/record/275879},
}