000275880 001__ 275880
000275880 005__ 20250120165733.0
000275880 0247_ $$2doi$$a10.1016/B978-0-443-22194-1.00021-5
000275880 037__ $$aDZNE-2025-00115
000275880 1001_ $$0P:(DE-2719)9001992$$aFavila, Natalia$$b0$$udzne
000275880 245__ $$aRole of the substance P in learning and memory
000275880 260__ $$bElsevier$$c2025
000275880 29510 $$aSubstance P / Favila, Natalia ; : Elsevier, 2025, ; ISBN: 9780443221941 ; doi:10.1016/B978-0-443-22194-1.00021-5
000275880 300__ $$a159 - 178
000275880 3367_ $$2ORCID$$aBOOK_CHAPTER
000275880 3367_ $$07$$2EndNote$$aBook Section
000275880 3367_ $$2DRIVER$$abookPart
000275880 3367_ $$2BibTeX$$aINBOOK
000275880 3367_ $$2DataCite$$aOutput Types/Book chapter
000275880 3367_ $$0PUB:(DE-HGF)7$$2PUB:(DE-HGF)$$aContribution to a book$$bcontb$$mcontb$$s1737365836_5001
000275880 520__ $$aSubstance P (SP), which is part of the tachykinin family, is an undecapeptide. The peptide and its receptors are present throughout the brain, including structures, such as the amygdala, hippocampus, and striatum, which have an acknowledged role in learning and memory. Despite some uncertainties regarding SP capability to cross the blood-brain barrier, an overwhelming body of research, including systemic intervention, knockout models, and targeted intracerebral injections of SP or its antagonists, strongly supports the involvement of SP in learning and memory. In this review, we discuss an involvement of SP in nonassociative (habituation and sensitization) and associative learning, focusing on classical conditioning (place preference conditioning and place aversion) and operant conditioning (avoidance learning, conditioned lever pressing, and maze learning), and extend into the acquisition of more complex behaviors such as those involved in the 5-choice serial reaction time task and in the memories that underlie learned and hard-wired innate serial behaviors. In classical conditioning, SP can act as an unconditioned stimulus, although its role in the associative process per se is unclear. In operant conditioning, evidence suggests that SP interacts with other neuromodulators, in particular, dopamine, acetylcholine, and opioids in reward prediction to influence learning directly. A similar mechanism has been suggested to underlie the involvement of SP in the acquisition of behavioral sequences. Additional research is required in several areas, particularly in the fields of human psychopharmacology and computational neuroscience. These endeavors are essential to strengthen the specific role of SP in learning and memory, and for formulating new hypotheses regarding the underlying mechanisms of the effects of SP.
000275880 536__ $$0G:(DE-HGF)POF4-351$$a351 - Brain Function (POF4-351)$$cPOF4-351$$fPOF IV$$x0
000275880 588__ $$aDataset connected to CrossRef Book
000275880 7001_ $$aOverton, Paul G.$$b1
000275880 773__ $$a10.1016/B978-0-443-22194-1.00021-5
000275880 909CO $$ooai:pub.dzne.de:275880$$pVDB
000275880 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9001992$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b0$$kDZNE
000275880 9131_ $$0G:(DE-HGF)POF4-351$$1G:(DE-HGF)POF4-350$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lNeurodegenerative Diseases$$vBrain Function$$x0
000275880 9141_ $$y2025
000275880 9201_ $$0I:(DE-2719)5000059$$kAG Krabbe$$lFunctional Diversity of Neural Circuits$$x0
000275880 980__ $$acontb
000275880 980__ $$aVDB
000275880 980__ $$aI:(DE-2719)5000059
000275880 980__ $$aUNRESTRICTED