% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@INBOOK{Favila:275880,
      author       = {Favila, Natalia and Overton, Paul G.},
      title        = {{R}ole of the substance {P} in learning and memory},
      publisher    = {Elsevier},
      reportid     = {DZNE-2025-00115},
      pages        = {159 - 178},
      year         = {2025},
      comment      = {Substance P / Favila, Natalia ; : Elsevier, 2025, ; ISBN:
                      9780443221941 ; doi:10.1016/B978-0-443-22194-1.00021-5},
      booktitle     = {Substance P / Favila, Natalia ; :
                       Elsevier, 2025, ; ISBN: 9780443221941 ;
                       doi:10.1016/B978-0-443-22194-1.00021-5},
      abstract     = {Substance P (SP), which is part of the tachykinin family,
                      is an undecapeptide. The peptide and its receptors are
                      present throughout the brain, including structures, such as
                      the amygdala, hippocampus, and striatum, which have an
                      acknowledged role in learning and memory. Despite some
                      uncertainties regarding SP capability to cross the
                      blood-brain barrier, an overwhelming body of research,
                      including systemic intervention, knockout models, and
                      targeted intracerebral injections of SP or its antagonists,
                      strongly supports the involvement of SP in learning and
                      memory. In this review, we discuss an involvement of SP in
                      nonassociative (habituation and sensitization) and
                      associative learning, focusing on classical conditioning
                      (place preference conditioning and place aversion) and
                      operant conditioning (avoidance learning, conditioned lever
                      pressing, and maze learning), and extend into the
                      acquisition of more complex behaviors such as those involved
                      in the 5-choice serial reaction time task and in the
                      memories that underlie learned and hard-wired innate serial
                      behaviors. In classical conditioning, SP can act as an
                      unconditioned stimulus, although its role in the associative
                      process per se is unclear. In operant conditioning, evidence
                      suggests that SP interacts with other neuromodulators, in
                      particular, dopamine, acetylcholine, and opioids in reward
                      prediction to influence learning directly. A similar
                      mechanism has been suggested to underlie the involvement of
                      SP in the acquisition of behavioral sequences. Additional
                      research is required in several areas, particularly in the
                      fields of human psychopharmacology and computational
                      neuroscience. These endeavors are essential to strengthen
                      the specific role of SP in learning and memory, and for
                      formulating new hypotheses regarding the underlying
                      mechanisms of the effects of SP.},
      cin          = {AG Krabbe},
      cid          = {I:(DE-2719)5000059},
      pnm          = {351 - Brain Function (POF4-351)},
      pid          = {G:(DE-HGF)POF4-351},
      typ          = {PUB:(DE-HGF)7},
      doi          = {10.1016/B978-0-443-22194-1.00021-5},
      url          = {https://pub.dzne.de/record/275880},
}