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| 001 | 275880 | ||
| 005 | 20250120165733.0 | ||
| 024 | 7 | _ | |a 10.1016/B978-0-443-22194-1.00021-5 |2 doi |
| 037 | _ | _ | |a DZNE-2025-00115 |
| 100 | 1 | _ | |a Favila, Natalia |0 P:(DE-2719)9001992 |b 0 |u dzne |
| 245 | _ | _ | |a Role of the substance P in learning and memory |
| 260 | _ | _ | |c 2025 |b Elsevier |
| 295 | 1 | 0 | |a Substance P / Favila, Natalia ; : Elsevier, 2025, ; ISBN: 9780443221941 ; doi:10.1016/B978-0-443-22194-1.00021-5 |
| 300 | _ | _ | |a 159 - 178 |
| 336 | 7 | _ | |a BOOK_CHAPTER |2 ORCID |
| 336 | 7 | _ | |a Book Section |0 7 |2 EndNote |
| 336 | 7 | _ | |a bookPart |2 DRIVER |
| 336 | 7 | _ | |a INBOOK |2 BibTeX |
| 336 | 7 | _ | |a Output Types/Book chapter |2 DataCite |
| 336 | 7 | _ | |a Contribution to a book |b contb |m contb |0 PUB:(DE-HGF)7 |s 1737365836_5001 |2 PUB:(DE-HGF) |
| 520 | _ | _ | |a Substance P (SP), which is part of the tachykinin family, is an undecapeptide. The peptide and its receptors are present throughout the brain, including structures, such as the amygdala, hippocampus, and striatum, which have an acknowledged role in learning and memory. Despite some uncertainties regarding SP capability to cross the blood-brain barrier, an overwhelming body of research, including systemic intervention, knockout models, and targeted intracerebral injections of SP or its antagonists, strongly supports the involvement of SP in learning and memory. In this review, we discuss an involvement of SP in nonassociative (habituation and sensitization) and associative learning, focusing on classical conditioning (place preference conditioning and place aversion) and operant conditioning (avoidance learning, conditioned lever pressing, and maze learning), and extend into the acquisition of more complex behaviors such as those involved in the 5-choice serial reaction time task and in the memories that underlie learned and hard-wired innate serial behaviors. In classical conditioning, SP can act as an unconditioned stimulus, although its role in the associative process per se is unclear. In operant conditioning, evidence suggests that SP interacts with other neuromodulators, in particular, dopamine, acetylcholine, and opioids in reward prediction to influence learning directly. A similar mechanism has been suggested to underlie the involvement of SP in the acquisition of behavioral sequences. Additional research is required in several areas, particularly in the fields of human psychopharmacology and computational neuroscience. These endeavors are essential to strengthen the specific role of SP in learning and memory, and for formulating new hypotheses regarding the underlying mechanisms of the effects of SP. |
| 536 | _ | _ | |a 351 - Brain Function (POF4-351) |0 G:(DE-HGF)POF4-351 |c POF4-351 |f POF IV |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef Book |
| 700 | 1 | _ | |a Overton, Paul G. |b 1 |
| 773 | _ | _ | |a 10.1016/B978-0-443-22194-1.00021-5 |
| 909 | C | O | |o oai:pub.dzne.de:275880 |p VDB |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 0 |6 P:(DE-2719)9001992 |
| 913 | 1 | _ | |a DE-HGF |b Gesundheit |l Neurodegenerative Diseases |1 G:(DE-HGF)POF4-350 |0 G:(DE-HGF)POF4-351 |3 G:(DE-HGF)POF4 |2 G:(DE-HGF)POF4-300 |4 G:(DE-HGF)POF |v Brain Function |x 0 |
| 914 | 1 | _ | |y 2025 |
| 920 | 1 | _ | |0 I:(DE-2719)5000059 |k AG Krabbe |l Functional Diversity of Neural Circuits |x 0 |
| 980 | _ | _ | |a contb |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a I:(DE-2719)5000059 |
| 980 | _ | _ | |a UNRESTRICTED |
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