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000275881 1001_ $$0P:(DE-2719)9002951$$aDörner, Marc$$b0$$eFirst author$$udzne
000275881 245__ $$aCross-sectional study on the impact of adverse childhood experiences on psychological distress in patients with an implantable cardioverter-defibrillator.
000275881 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2025
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000275881 520__ $$aPrevious studies implied detrimental effects of adverse childhood experiences (ACE) on cardiovascular disease and mental health. Still, data on the influence of ACE on psychological distress in patients with an implantable cardioverter-defibrillator (ICD) are lacking.We prospectively recruited 423 patients with an ICD. To determine associations between ACE (ACE questionnaire, cut-off ≥4), depression (Patient Health Questionnaire-8), anxiety (Generalized Anxiety Disorder-7 scale), and post-traumatic stress disorder (PTSD) symptoms (Post-Traumatic Stress Diagnostic Scale), we conducted a binary logistic regression analysis. Regression models were adjusted for conventional risk factors of psychological distress in ICD patients. To identify indirect mediating effects of resilience (Resilience Scale) on ACE and psychological distress, we applied the PROCESS regression path analysis modeling tool.49.1 % of all patients reported at least one ACE, and 9.7 % experienced even four or more ACE. A high-risk ACE profile (≥ 4) was associated with higher levels of anxiety (OR 3.68, 95 % CI 1.37-9.84, p = 0.009), depression (OR 4.08, 95 % CI 1.67-9.97, p = 0.002), and PTSD symptoms (OR 2.20, 95 % CI 1.03-5.21, p = 0.041). Greater resilience partially mediated the relationship between ACE and depression (indirect effect 0.11, 95 % CI 0.01-0.26) as well as anxiety (indirect effect 0.08, 95 % CI 0.008-0.19).The current study suggests an association between ACE and psychological distress in patients with an ICD. However, resilience could mitigate the adverse effects of ACE. Future studies should strive to unravel the complex mechanisms of ACE and its effects on cardiovascular and mental health in ICD patients.
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000275881 650_7 $$2Other$$aAdverse childhood experiences
000275881 650_7 $$2Other$$aAnxiety
000275881 650_7 $$2Other$$aDepression
000275881 650_7 $$2Other$$aImplantable cardioverter-defibrillator
000275881 650_7 $$2Other$$aPost-traumatic stress disorder
000275881 650_7 $$2Other$$aResilience
000275881 650_2 $$2MeSH$$aHumans
000275881 650_2 $$2MeSH$$aDefibrillators, Implantable: psychology
000275881 650_2 $$2MeSH$$aFemale
000275881 650_2 $$2MeSH$$aMale
000275881 650_2 $$2MeSH$$aCross-Sectional Studies
000275881 650_2 $$2MeSH$$aMiddle Aged
000275881 650_2 $$2MeSH$$aPsychological Distress
000275881 650_2 $$2MeSH$$aAdverse Childhood Experiences
000275881 650_2 $$2MeSH$$aStress Disorders, Post-Traumatic: psychology
000275881 650_2 $$2MeSH$$aAnxiety: psychology
000275881 650_2 $$2MeSH$$aAged
000275881 650_2 $$2MeSH$$aDepression: psychology
000275881 650_2 $$2MeSH$$aAdult
000275881 650_2 $$2MeSH$$aResilience, Psychological
000275881 650_2 $$2MeSH$$aProspective Studies
000275881 650_2 $$2MeSH$$aRisk Factors
000275881 650_2 $$2MeSH$$aStress, Psychological: psychology
000275881 7001_ $$avon Känel, Roland$$b1
000275881 7001_ $$aPazhenkottil, Aju P$$b2
000275881 7001_ $$aAltwegg, Rahel$$b3
000275881 7001_ $$aKönig, Noelle$$b4
000275881 7001_ $$aNager, Ladina$$b5
000275881 7001_ $$aAttanasio, Veronica$$b6
000275881 7001_ $$aGuth, Lisa$$b7
000275881 7001_ $$aZirngast, Sina$$b8
000275881 7001_ $$aMenzi, Anna$$b9
000275881 7001_ $$aPrincip, Mary$$b10
000275881 7001_ $$aZuccarella-Hackl, Claudia$$b11
000275881 773__ $$0PERI:(DE-600)1500642-6$$a10.1016/j.jpsychores.2024.112033$$gVol. 189, p. 112033 -$$p112033$$tJournal of psychosomatic research$$v189$$x0022-3999$$y2025
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