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@ARTICLE{Vinci:275885,
      author       = {Vinci, Ersilia and Beretta, Stefania and Colombo, Veronica
                      and Zippo, Antonio and Catanese, Alberto and Wiegreffe,
                      Christoph and Britsch, Stefan and Boeckers, Tobias and
                      Verpelli, Chiara and Sala, Carlo},
      title        = {{R}egulation of {D}endrite and {D}endritic {S}pine
                      {F}ormation by {TCF}20.},
      journal      = {Journal of neurochemistry},
      volume       = {169},
      number       = {1},
      issn         = {0022-3042},
      address      = {Oxford},
      publisher    = {Wiley-Blackwell},
      reportid     = {DZNE-2025-00120},
      pages        = {e16297},
      year         = {2025},
      abstract     = {Mutations in the Transcription Factor 20 (TCF20) have been
                      identified in patients with autism spectrum disorders
                      (ASDs), intellectual disabilities (IDs), and other
                      neurological issues. Recently, a new syndrome called
                      TCF20-associated neurodevelopmental disorders (TAND) has
                      been described, with specific clinical features. While
                      TCF20's role in the neurogenesis of mouse embryos has been
                      reported, little is known about its molecular function in
                      neurons. In this study, we demonstrate that TCF20 is
                      expressed in all analyzed brain regions in mice, and its
                      expression increases during brain development but decreases
                      in muscle tissue. Our findings suggest that TCF20 plays a
                      central role in dendritic arborization and dendritic spine
                      formation processes. RNA sequencing analysis revealed a
                      downregulation of pre- and postsynaptic pathways in TCF20
                      knockdown neurons. We also found decreased levels of GABRA1,
                      BDNF, PSD-95, and c-Fos in total homogenates and in
                      synaptosomal preparations of knockdown TCF20 rat cortical
                      cultures. Furthermore, synaptosomal preparations of
                      knockdown TCF20 rat cortical cultures showed significant
                      downregulation of GluN2B and GABRA5, while GluA2 was
                      significantly upregulated. Overall, our data suggest that
                      TCF20 plays an essential role in neuronal development and
                      function by modulating the expression of proteins involved
                      in dendrite and synapse formation and function.},
      keywords     = {Animals / Dendritic Spines: metabolism / Dendrites:
                      metabolism / Mice / Rats / Cells, Cultured / Male / Mice,
                      Inbred C57BL / Neurogenesis: physiology / Female / BDNF
                      (Other) / dendritic spines (Other) / nruodevelopmental
                      disease (Other) / synapses (Other)},
      cin          = {AG Böckers},
      ddc          = {610},
      cid          = {I:(DE-2719)1910002},
      pnm          = {352 - Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)16},
      pmc          = {pmc:PMC11725998},
      pubmed       = {pmid:39801227},
      doi          = {10.1111/jnc.16297},
      url          = {https://pub.dzne.de/record/275885},
}