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@ARTICLE{Lowinski:275886,
      author       = {Lowinski, Anna and Dabringhaus, Andreas and Kraemer,
                      Matthias and Doshi, Hardik and Weier, Alicia and Hintze,
                      Maik and Chunder, Rittika and Kuerten, Stefanie},
      title        = {{MRI}-based morphometric structural changes correlate with
                      histopathology in experimental autoimmune
                      encephalomyelitis.},
      journal      = {Journal of the neurological sciences},
      volume       = {468},
      issn         = {0022-510X},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DZNE-2025-00121},
      pages        = {123358},
      year         = {2025},
      abstract     = {Magnetic resonance imaging (MRI) and neurohistopathology
                      are important correlates for evaluation of disease
                      progression in multiple sclerosis (MS). Here we used
                      experimental autoimmune encephalomyelitis (EAE) as an animal
                      model of MS to determine the correlation between clinical
                      EAE severity, MRI and histopathological parameters.N = 11
                      female C57BL/6J mice were immunized with human myelin
                      oligodendrocyte glycoprotein 1-125, while N = 9 remained
                      non-immunized. Mice were scanned longitudinally over a
                      period of 13 weeks using a 11.7 Tesla (T) Bruker BioSpec®
                      preclinical MRI instrument, and regional volume changes of
                      the lumbar spinal cord were analyzed using Voxel-Guided
                      Morphometry (VGM). Following the final in vivo T1-weighted
                      MRI scan, the lumbar spinal cord of each mouse was subjected
                      to an ex vivo MRI scan using T1-, T2*- and diffusion tensor
                      imaging (DTI)-weighted sequences. Tissue sections were then
                      stained for immune cell infiltration, demyelination,
                      astrogliosis, and axonal damage using hematoxylin-eosin
                      staining and immunohistochemistry.While in vivo MRI VGM
                      detected an overall increase in volume over time, no
                      differences were observed between EAE animals and controls.
                      Ex vivo MRI showed a generalized atrophy of the spinal cord,
                      which was pronounced in the anterolateral tract. The most
                      striking correlation was observed between EAE score, white
                      matter atrophy in ex vivo T1-weighted scans and histological
                      parameters.The data demonstrate that ex vivo MRI is a
                      valuable tool to assess white matter atrophy in EAE, which
                      was shown to be directly linked to the severity of EAE and
                      spinal cord histopathology.},
      keywords     = {Encephalomyelitis, Autoimmune, Experimental: pathology /
                      Encephalomyelitis, Autoimmune, Experimental: diagnostic
                      imaging / Animals / Female / Mice, Inbred C57BL / Magnetic
                      Resonance Imaging: methods / Spinal Cord: pathology / Spinal
                      Cord: diagnostic imaging / Mice / Disease Models, Animal /
                      Myelin-Oligodendrocyte Glycoprotein: immunology / Diffusion
                      Tensor Imaging: methods / Experimental autoimmune
                      encephalomyelitis (Other) / Magnetic resonance imaging
                      (Other) / Multiple sclerosis (Other) / T1 (Other) / T2
                      (Other) / T2* (Other) / Voxel-guided morphometry (Other) /
                      Myelin-Oligodendrocyte Glycoprotein (NLM Chemicals)},
      cin          = {SAMRI / CRFS},
      ddc          = {610},
      cid          = {I:(DE-2719)1040270 / I:(DE-2719)1040000},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39729930},
      doi          = {10.1016/j.jns.2024.123358},
      url          = {https://pub.dzne.de/record/275886},
}