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@ARTICLE{Stengl:275907,
author = {Stengl, Helena and Poller, Wolfram C and Di Vece, Davide
and Templin, Christian and Endres, Matthias and Nolte,
Christian H and Scheitz, Jan F},
title = {{H}ow the brain impacts the heart: lessons from ischaemic
stroke and other neurological disorders.},
journal = {British heart journal},
volume = {111},
number = {3},
issn = {0007-0769},
address = {London},
publisher = {BMJ Publ. Group},
reportid = {DZNE-2025-00140},
pages = {99 - 108},
year = {2025},
note = {ISSN 1468-201X not unique: **2 hits**.},
abstract = {Cardiovascular alterations are common in patients who had
ischaemic stroke, haemorrhagic stroke and other acute brain
disorders such as seizures. These cardiac complications are
important drivers of morbidity and mortality and comprise
blood-based detection of cardiomyocyte damage, ECG changes,
heart failure and arrhythmia. Recently, the concept of a
distinct 'stroke-heart syndrome' has been formulated as a
pathophysiological framework for poststroke cardiac
complications. The concept considers cardiac sequelae after
stroke to be the result of a stroke-induced disturbance of
the brain-heart axis. In this review, we describe the
spectrum of cardiac changes secondary to ischaemic stroke
and other acute brain disorders. Furthermore, we focus on
Takotsubo syndrome secondary to acute brain disorders as a
model disease of disturbed brain-heart interaction. Finally,
we aim to provide an overview of the anatomical and
functional links between the brain and the heart, with
emphasis on the autonomic network and the role of
inflammation. Given the clinical relevance of the
deleterious impact of acute brain injury on the heart, we
call for clinical awareness and for starting joint efforts
combining expertise of neurology and cardiology to identify
specific therapeutic interventions.},
subtyp = {Review Article},
keywords = {Humans / Ischemic Stroke: physiopathology / Ischemic
Stroke: etiology / Brain: physiopathology / Heart:
physiopathology / Takotsubo Cardiomyopathy: physiopathology
/ Takotsubo Cardiomyopathy: etiology / Takotsubo
Cardiomyopathy: diagnosis / Heart Diseases: etiology / Heart
Diseases: physiopathology / Arrhythmias, Cardiac (Other) /
Biomarkers (Other) / Cardiovascular Diseases (Other) /
Inflammation (Other) / Stroke (Other)},
cin = {AG Endres},
ddc = {610},
cid = {I:(DE-2719)1811005},
pnm = {353 - Clinical and Health Care Research (POF4-353)},
pid = {G:(DE-HGF)POF4-353},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:39515993},
doi = {10.1136/heartjnl-2024-324173},
url = {https://pub.dzne.de/record/275907},
}