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@ARTICLE{Blotenberg:275938,
      author       = {Blotenberg, Iris and Wittström, Felix and Michalowsky,
                      Bernhard and Platen, Moritz and Wucherer, Diana and Teipel,
                      Stefan and Hoffmann, Wolfgang and Thyrian, Jochen René},
      title        = {{M}odifiable risk factors and symptom progression in
                      dementia over up to 8 years-{R}esults of the {D}elp{H}i-{MV}
                      trial.},
      journal      = {Alzheimer's $\&$ dementia / Diagnosis, assessment $\&$
                      disease monitoring},
      volume       = {17},
      number       = {1},
      issn         = {2352-8729},
      address      = {Hoboken, NJ},
      publisher    = {Wiley},
      reportid     = {DZNE-2025-00160},
      pages        = {e70050},
      year         = {2025},
      abstract     = {This study investigated the association between modifiable
                      factors and symptom progression in dementia over up to 8
                      years.Multilevel growth curve models assessed the role of
                      modifiable risk factors (low education, hearing impairment
                      and its treatment, depression, physical inactivity, diabetes
                      and its treatment, smoking, hypertension and its treatment,
                      obesity, alcohol consumption, social isolation, and visual
                      impairment) on cognitive and functional trajectories in 353
                      people with dementia.Higher education was associated with
                      higher initial cognitive status but faster decline.
                      Antidiabetic medication was associated with slower cognitive
                      decline, whereas depression and visual impairment were
                      linked to low baseline functioning and faster cognitive
                      decline.Several modifiable risk factors influenced symptom
                      progression. Education initially had a protective effect,
                      whereas depressive symptoms were linked to worse symptom
                      progression. Treatment of comorbidities (diabetes, visual
                      impairment) could have a positive impact on dementia
                      symptoms. Modifiable risk factors are promising targets for
                      tertiary prevention.Modifiable risk factors were associated
                      with symptom progression in dementia over up to 8 years.More
                      education was associated with higher initial cognitive
                      status but faster decline.Depressive symptoms were linked to
                      less favorable symptom progression.Treatment of
                      comorbidities (diabetes, visual impairment) may positively
                      impact the course of symptoms.Modifiable risk factors are
                      promising targets for tertiary prevention.},
      keywords     = {Alzheimer Disease (Other) / activities of daily living
                      (Other) / anti‐diabetic medication (Other) / cognition
                      (Other) / cognitive decline (Other) / comorbidities (Other)
                      / depressive symptoms (Other) / education (Other) /
                      functional decline (Other) / lifestyle (Other) / medication
                      (Other) / visual impairment (Other)},
      cin          = {AG Thyrian / AG Michalowsky / AG Hoffmann / AG Teipel},
      ddc          = {610},
      cid          = {I:(DE-2719)1510800 / I:(DE-2719)5000067 /
                      I:(DE-2719)1510600 / I:(DE-2719)1510100},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39811699},
      pmc          = {pmc:PMC11730075},
      doi          = {10.1002/dad2.70050},
      url          = {https://pub.dzne.de/record/275938},
}