TY  - JOUR
AU  - Bauer, Theresa
AU  - Brendel, Matthias
AU  - Zaganjori, Mirlind
AU  - Bernhardt, Alexander M
AU  - Jäck, Alexander
AU  - Stöcklein, Sophia
AU  - Scheifele, Maximilian
AU  - Levin, Johannes
AU  - van Eimeren, Thilo
AU  - Drzezga, Alexander
AU  - Sabri, Osama
AU  - Barthel, Henryk
AU  - Perneczky, Robert
AU  - Höglinger, Günter
AU  - Franzmeier, Nicolai
AU  - Gnörich, Johannes
TI  - Pragmatic algorithm for visual assessment of 4-Repeat tauopathies in [18F]PI-2620 PET Scans.
JO  - NeuroImage
VL  - 306
SN  - 1053-8119
CY  - Orlando, Fla.
PB  - Academic Press
M1  - DZNE-2025-00163
SP  - 121001
PY  - 2025
AB  - Standardized evaluation of [18F]PI-2620 tau-PET scans in 4R-tauopathies represents an unmet need in clinical practice. This study aims to investigate the effectiveness of visual evaluation of [18F]PI-2620 images for diagnosing 4R-tauopathies and to develop a straight-forward reading algorithm to improve objectivity and data reproducibility.A total of 83 individuals with [18F]PI-2620 PET scans were included. Participants were classified as probable 4R-tauopathies (n = 29), Alzheimer's disease (AD) (n = 20), α-synucleinopathies (n = 15), and healthy controls (n = 19) based on clinical criteria. Visual assessment of tau-PET scans (choice: 4R-tauopathy, AD-tauopathy, no-tauopathy) was conducted using either 20-40-minute or 40-60-minute intervals, with raw (common) and cerebellar grey matter scaled standardized reading settings (intensity-scaled). Two readers evaluated scans independently and blinded, with a third reader providing consensus in case of discrepant primary evaluation. A regional analysis was performed using the cortex, basal ganglia, midbrain, and dentate nucleus. Sensitivity, specificity, and interrater agreement were calculated for all settings and compared against the visual reads of parametric images (0-60-minutes, distribution volume ratios, DVR).Patients with 4R-tauopathies in contrast to non-4R-tauopathies were detected at higher sensitivity in the 20-40-minute frame (common: 79
KW  - Reading algorithm (Other)
KW  - Tau-PET (Other)
KW  - Tauopathies (Other)
KW  - Visual read (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:39798829
DO  - DOI:10.1016/j.neuroimage.2025.121001
UR  - https://pub.dzne.de/record/275967
ER  -