TY - JOUR AU - Falso, Silvia AU - Zara, Pietro AU - Marini, Sofia AU - Puci, Mariangela AU - Sabatelli, Eleonora AU - Sotgiu, Giovanni AU - Marini, Martina AU - Spagni, Gregorio AU - Evoli, Amelia AU - Solla, Paolo AU - Iorio, Raffaele AU - Sechi, Elia TI - Seasonal variation in myasthenia gravis incidence. JO - Journal of neuroimmunology VL - 399 SN - 0165-5728 CY - Amsterdam [u.a.] PB - Elsevier Science M1 - DZNE-2025-00164 SP - 578524 PY - 2025 AB - Environmental factors may contribute to myasthenia gravis (MG) development, sometimes with seasonal patterns of exposure. However, whether seasonality has an impact on MG incidence remains unclear. We aimed to investigate the association between seasonality and MG onset.We reviewed data of MG patients with acetylcholine receptor (AChR)-IgG and disease onset between January 2010-December 2019, from two Italian cohorts: 1) an hospital-based cohort and 2) a population-based cohort. MG cases were assigned to four season-trimesters based on month of onset to determine seasonal association with MG incidence.We enrolled 316 patients:214 in the hospital-based and 102 in the population-based cohort. Median age at onset was 66 years (range, 8-92); Female accounted for 41.1 KW - AChR-IgG (Other) KW - Epidemiology (Other) KW - Onset (Other) KW - Presentation (Other) KW - Risk (Other) LB - PUB:(DE-HGF)16 C6 - pmid:39799766 DO - DOI:10.1016/j.jneuroim.2025.578524 UR - https://pub.dzne.de/record/275968 ER -