TY  - JOUR
AU  - Falso, Silvia
AU  - Zara, Pietro
AU  - Marini, Sofia
AU  - Puci, Mariangela
AU  - Sabatelli, Eleonora
AU  - Sotgiu, Giovanni
AU  - Marini, Martina
AU  - Spagni, Gregorio
AU  - Evoli, Amelia
AU  - Solla, Paolo
AU  - Iorio, Raffaele
AU  - Sechi, Elia
TI  - Seasonal variation in myasthenia gravis incidence.
JO  - Journal of neuroimmunology
VL  - 399
SN  - 0165-5728
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - DZNE-2025-00164
SP  - 578524
PY  - 2025
AB  - Environmental factors may contribute to myasthenia gravis (MG) development, sometimes with seasonal patterns of exposure. However, whether seasonality has an impact on MG incidence remains unclear. We aimed to investigate the association between seasonality and MG onset.We reviewed data of MG patients with acetylcholine receptor (AChR)-IgG and disease onset between January 2010-December 2019, from two Italian cohorts: 1) an hospital-based cohort and 2) a population-based cohort. MG cases were assigned to four season-trimesters based on month of onset to determine seasonal association with MG incidence.We enrolled 316 patients:214 in the hospital-based and 102 in the population-based cohort. Median age at onset was 66 years (range, 8-92); Female accounted for 41.1 
KW  - AChR-IgG (Other)
KW  - Epidemiology (Other)
KW  - Onset (Other)
KW  - Presentation (Other)
KW  - Risk (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:39799766
DO  - DOI:10.1016/j.jneuroim.2025.578524
UR  - https://pub.dzne.de/record/275968
ER  -