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@ARTICLE{Falso:275968,
      author       = {Falso, Silvia and Zara, Pietro and Marini, Sofia and Puci,
                      Mariangela and Sabatelli, Eleonora and Sotgiu, Giovanni and
                      Marini, Martina and Spagni, Gregorio and Evoli, Amelia and
                      Solla, Paolo and Iorio, Raffaele and Sechi, Elia},
      title        = {{S}easonal variation in myasthenia gravis incidence.},
      journal      = {Journal of neuroimmunology},
      volume       = {399},
      issn         = {0165-5728},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DZNE-2025-00164},
      pages        = {578524},
      year         = {2025},
      abstract     = {Environmental factors may contribute to myasthenia gravis
                      (MG) development, sometimes with seasonal patterns of
                      exposure. However, whether seasonality has an impact on MG
                      incidence remains unclear. We aimed to investigate the
                      association between seasonality and MG onset.We reviewed
                      data of MG patients with acetylcholine receptor (AChR)-IgG
                      and disease onset between January 2010-December 2019, from
                      two Italian cohorts: 1) an hospital-based cohort and 2) a
                      population-based cohort. MG cases were assigned to four
                      season-trimesters based on month of onset to determine
                      seasonal association with MG incidence.We enrolled 316
                      patients:214 in the hospital-based and 102 in the
                      population-based cohort. Median age at onset was 66 years
                      (range, 8-92); Female accounted for 41.1 $\%.$ The median
                      number of new MG cases per season-trimester was
                      significantly higher in summer than other trimesters (p =
                      0.009), and associated with higher environmental
                      temperatures.Our findings suggest that MG onset may be more
                      common in summer and at higher environmental temperatures.
                      Identifying the determinants of this association may improve
                      our understanding of disease pathophysiology.},
      keywords     = {AChR-IgG (Other) / Epidemiology (Other) / Onset (Other) /
                      Presentation (Other) / Risk (Other)},
      cin          = {AG Prüß},
      ddc          = {610},
      cid          = {I:(DE-2719)1810003},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39799766},
      doi          = {10.1016/j.jneuroim.2025.578524},
      url          = {https://pub.dzne.de/record/275968},
}