TY  - JOUR
AU  - Guilbaud, Lucie
AU  - Roger, Kévin
AU  - Schmidt, Andree
AU  - Chhuon, Cerina
AU  - Breimann, Stephan
AU  - Lipecka, Joanna
AU  - Dreux, Sophie
AU  - Müller, Stephan A
AU  - Zérah, Michel
AU  - Larghero, Jérôme
AU  - Jouannic, Jean-Marie
AU  - Lichtenthaler, Stefan F
AU  - Guerrera, Ida C
TI  - Molecular insights into myelomeningocele via proteomic analysis of amniotic fluid.
JO  - Journal of proteomics
VL  - 313
SN  - 1874-3919
CY  - New York, NY [u.a.]
PB  - Elsevier
M1  - DZNE-2025-00165
SP  - 105372
PY  - 2025
AB  - Despite numerous studies on fetal therapy for myelomeningoceles (MMC), the pathophysiology of this malformation remains poorly understood. This study aimed to analyze the biochemical profile and proteome of amniotic fluid (AF) supernatants from MMC fetuses to explore the prenatal pathophysiology. Biochemical analysis of 61 AF samples from MMC fetuses was compared with 45 healthy fetuses' samples. Proteome analysis was conducted in 18 MMC and 18 healthy singleton fetuses, and in 5 dichorionic pregnancies with MMC fetuses and their healthy co-twins. ELISA tests were used to validate proteome results. Biochemical analysis revealed anal incontinence in 37 
KW  - Amniotic fluid (Other)
KW  - BACE1 (Other)
KW  - Myelomeningocele (Other)
KW  - Pathophysiology (Other)
KW  - Proteomics (Other)
KW  - Spina bifida (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:39778765
DO  - DOI:10.1016/j.jprot.2024.105372
UR  - https://pub.dzne.de/record/275969
ER  -