TY  - JOUR
AU  - Teipel, Stefan
AU  - Akmatov, Manas
AU  - Michalowsky, Bernhard
AU  - Riedel-Heller, Steffi
AU  - Bohlken, Jens
AU  - Holstiege, Jakob
TI  - Timing of risk factors, prodromal features, and comorbidities of dementia from a large health claims case-control study.
JO  - Alzheimer's research & therapy
VL  - 17
IS  - 1
SN  - 1758-9193
CY  - London
PB  - BioMed Central
M1  - DZNE-2025-00168
SP  - 22
PY  - 2025
AB  - Many risk factors for dementia have been identified, but the timing of risk is less well understood. Here, we analyzed risk factors in a case-control study covering 10 years before an incident dementia diagnosis.We designed a case-control study using insurance claims of outpatient consultations of patients with German statutory health insurance between January 1, 2012, and December 31, 2022. We included patients with an incident diagnosis of dementia and controls without a diagnosis of dementia matched 1:2 for age, sex, region, and earliest year of outpatient encounter. We selected exposures based on previous systematic reviews, case-control and cohort studies reporting on risk factors, comorbidities, and prodromal features of dementia. We calculated the prevalence of risk factors in cases and controls and odds ratios for each year before the index date, along with Bonferroni-corrected confidence intervals, using conditional logistic regression.We identified a total of 1,686,759 patients with incident dementia (mean (SD) age, 82.15 (6.90) years; 61.70
KW  - Humans
KW  - Female
KW  - Male
KW  - Case-Control Studies
KW  - Dementia: epidemiology
KW  - Risk Factors
KW  - Prodromal Symptoms
KW  - Comorbidity
KW  - Aged, 80 and over
KW  - Aged
KW  - Germany: epidemiology
KW  - Time Factors
KW  - Prevalence
KW  - Behavioral disorders (Other)
KW  - Cancer (Other)
KW  - Dementia incidence (Other)
KW  - Health claims data (Other)
KW  - Hypertension (Other)
KW  - Odds ratio (Other)
KW  - Risk trajectory (Other)
LB  - PUB:(DE-HGF)16
C2  - pmc:PMC11736938
C6  - pmid:39819557
DO  - DOI:10.1186/s13195-024-01662-x
UR  - https://pub.dzne.de/record/276087
ER  -