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@ARTICLE{Soch:276103,
      author       = {Soch, Joram and Richter, Anni and Kizilirmak, Jasmin M. and
                      Schütze, Hartmut and Altenstein, Slawek and Dechent, Peter
                      and Fliessbach, Klaus and Glanz, Wenzel and Herrera, Ana
                      Lucia and Hetzer, Stefan and Incesoy, Enise I. and Kilimann,
                      Ingo and Kimmich, Okka and Lammerding, Dominik and Laske,
                      Christoph and Lohse, Andrea and Lüsebrink, Falk and Munk,
                      Matthias H. and Peters, Oliver and Preis, Lukas and Priller,
                      Josef and Rostamzadeh, Ayda and Roy-Kluth, Nina and
                      Scheffler, Klaus and Schneider, Anja and Spottke, Annika and
                      Spruth, Eike Jakob and Teipel, Stefan and Wiltfang, Jens and
                      Jessen, Frank and Düzel, Emrah and Schott, Björn H.},
      title        = {{R}educed expression of f{MRI} subsequent memory effects
                      with increasing severity across the {A}lzheimer’s disease
                      risk spectrum},
      journal      = {Imaging neuroscience},
      volume       = {2},
      issn         = {2837-6056},
      address      = {Cambridge, MA},
      publisher    = {MIT Press},
      reportid     = {DZNE-2025-00184},
      pages        = {1 - 23},
      year         = {2024},
      abstract     = {In functional magnetic resonance imaging (fMRI) studies,
                      episodic memory is commonly investigated with the subsequent
                      memory paradigm in which brain activity is recorded during
                      encoding and analyzed as a function of subsequent
                      remembering and forgetting. Impaired episodic memory is
                      common in individuals with or at risk for Alzheimer’s
                      disease (AD), but only few studies have reported subsequent
                      memory effects in AD or its risk states like mild cognitive
                      impairment (MCI). One reason for this might be that
                      subsequent memory responses may be blunted in AD or MCI and
                      thus less likely to manifest in fMRI signal differences.
                      Here, we used Bayesian model selection of single-subject
                      fMRI general linear models (GLMs) for a visual novelty and
                      memory encoding experiment to compare the model performance
                      of categorical and parametric subsequent memory models as
                      well as memory-invariant models in a clinical cohort (N =
                      468) comprising healthy controls (HC) as well as individuals
                      with subjective cognitive decline (SCD), MCI, and AD, plus
                      healthy relatives of AD patients (AD-rel). We could
                      replicate the previously reported superiority of parametric
                      subsequent memory models over categorical models (Soch,
                      Richter, Schütze, Kizilirmak, Assmann, Knopf, et al., 2021)
                      in the HC and also in the SCD and AD-rel groups. However,
                      memory-invariant models outperformed any model assuming
                      subsequent memory effects in the MCI and AD groups. In the
                      AD group, we additionally found substantially lower model
                      preference for models assuming novelty compared to models
                      not differentiating between novel and familiar stimuli. Our
                      results suggest that voxel-wise memory-related fMRI activity
                      patterns in AD and also MCI should be interpreted with
                      caution and point to the need for additional or alternative
                      approaches to investigate memory function.},
      cin          = {AG Fischer / Clinical Dementia Research (Göttingen) / AG
                      Wiltfang / AG Düzel / AG Endres / Patient Studies (Bonn) /
                      AG Teipel / Clinical Research (Bonn) / AG Gasser / AG Peters
                      / AG Priller / AG Spottke / Clinical Research Platform (CRP)
                      / AG Schneider / AG Jessen},
      ddc          = {610},
      cid          = {I:(DE-2719)1410002 / I:(DE-2719)1440015 /
                      I:(DE-2719)1410006 / I:(DE-2719)5000006 / I:(DE-2719)1811005
                      / I:(DE-2719)1011101 / I:(DE-2719)1510100 /
                      I:(DE-2719)1011001 / I:(DE-2719)1210000 / I:(DE-2719)5000000
                      / I:(DE-2719)5000007 / I:(DE-2719)1011103 /
                      I:(DE-2719)1011401 / I:(DE-2719)1011305 /
                      I:(DE-2719)1011102},
      pnm          = {352 - Disease Mechanisms (POF4-352) / 353 - Clinical and
                      Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-352 / G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      doi          = {10.1162/imag_a_00260},
      url          = {https://pub.dzne.de/record/276103},
}