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000276147 1001_ $$00000-0001-7064-9487$$aHerrera-Rivero, Marisol$$b0
000276147 245__ $$aA meta-analysis of genome-wide studies of resilience in the German population
000276147 260__ $$a[London]$$bSpringer Nature$$c2025
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000276147 520__ $$aResilience is the capacity to adapt to stressful life events. As such, this trait is associated with physical and mental functions and conditions. Here, we aimed to identify the genetic factors contributing to shape resilience. We performed variant- and gene-based meta-analyses of genome-wide association studies from six German cohorts (N = 15822) using the 11-item version of the Resilience Scale (RS-11) as outcome measure. Variant- and gene-level results were combined to explore the biological context using network analysis. In addition, we conducted tests of correlation between RS-11 and the polygenic scores (PGSs) for 12 personality and mental health traits in one of these cohorts (PROCAM-2, N = 3879). The variant-based analysis found no signals associated with resilience at the genome-wide level (p < 5 × 10-8), but suggested five genomic loci (p < 1 × 10-5). The gene-based analysis identified three genes (ROBO1, CIB3 and LYPD4) associated with resilience at genome-wide level (p < 2.48 × 10-6) and 32 potential candidates (p < 1 × 10-4). Network analysis revealed enrichment of biological pathways related to neuronal proliferation and differentiation, synaptic organization, immune responses and vascular homeostasis. We also found significant correlations (FDR < 0.05) between RS-11 and the PGSs for neuroticism and general happiness. Overall, our observations suggest low heritability of resilience. Large, international efforts will be required to uncover the genetic factors that contribute to shape trait resilience. Nevertheless, as the largest investigation of the genetics of resilience in general population to date, our study already offers valuable insights into the biology potentially underlying resilience and resilience's relationship with other personality traits and mental health.
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000276147 650_2 $$2MeSH$$aHumans
000276147 650_2 $$2MeSH$$aGenome-Wide Association Study: methods
000276147 650_2 $$2MeSH$$aResilience, Psychological
000276147 650_2 $$2MeSH$$aGermany
000276147 650_2 $$2MeSH$$aMultifactorial Inheritance: genetics
000276147 650_2 $$2MeSH$$aMale
000276147 650_2 $$2MeSH$$aFemale
000276147 650_2 $$2MeSH$$aPolymorphism, Single Nucleotide: genetics
000276147 650_2 $$2MeSH$$aPersonality: genetics
000276147 650_2 $$2MeSH$$aMental Health
000276147 650_2 $$2MeSH$$aAdult
000276147 650_2 $$2MeSH$$aCohort Studies
000276147 650_2 $$2MeSH$$aMiddle Aged
000276147 7001_ $$00000-0001-9067-8170$$aGarvert, Linda$$b1
000276147 7001_ $$00000-0002-5307-6936$$aHorn, Katrin$$b2
000276147 7001_ $$00000-0001-5984-8127$$aLöbner, Margrit$$b3
000276147 7001_ $$00000-0002-1469-1514$$aWeitzel, Elena Caroline$$b4
000276147 7001_ $$00000-0002-2711-4281$$aStoll, Monika$$b5
000276147 7001_ $$aLichtner, Peter$$b6
000276147 7001_ $$00000-0001-5807-5572$$aTeismann, Henning$$b7
000276147 7001_ $$00000-0002-8309-094X$$aTeumer, Alexander$$b8
000276147 7001_ $$0P:(DE-2719)9001174$$aVan der Auwera, Sandra$$b9
000276147 7001_ $$aVölzke, Henry$$b10
000276147 7001_ $$00000-0002-5689-3448$$aVölker, Uwe$$b11
000276147 7001_ $$00000-0002-2917-5889$$aAndlauer, Till F. M.$$b12
000276147 7001_ $$aMeinert, Susanne$$b13
000276147 7001_ $$aHeilmann-Heimbach, Stefanie$$b14
000276147 7001_ $$00000-0002-1876-6368$$aForstner, Andreas J.$$b15
000276147 7001_ $$00000-0003-1080-4339$$aStreit, Fabian$$b16
000276147 7001_ $$00000-0002-1571-1468$$aWitt, Stephanie H.$$b17
000276147 7001_ $$aKircher, Tilo$$b18
000276147 7001_ $$aDannlowski, Udo$$b19
000276147 7001_ $$0P:(DE-2719)9002639$$aScholz, Markus$$b20
000276147 7001_ $$00000-0003-4321-6090$$aRiedel-Heller, Steffi G.$$b21
000276147 7001_ $$0P:(DE-2719)2811781$$aGrabe, Hans J.$$b22$$udzne
000276147 7001_ $$aBaune, Bernhard T.$$b23
000276147 7001_ $$aBerger, Klaus$$b24
000276147 773__ $$0PERI:(DE-600)1502531-7$$a10.1038/s41380-024-02688-1$$gVol. 30, no. 2, p. 497 - 505$$n2$$p497 - 505$$tMolecular psychiatry$$v30$$x1359-4184$$y2025
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