% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{HerreraRivero:276147,
      author       = {Herrera-Rivero, Marisol and Garvert, Linda and Horn, Katrin
                      and Löbner, Margrit and Weitzel, Elena Caroline and Stoll,
                      Monika and Lichtner, Peter and Teismann, Henning and Teumer,
                      Alexander and Van der Auwera, Sandra and Völzke, Henry and
                      Völker, Uwe and Andlauer, Till F. M. and Meinert, Susanne
                      and Heilmann-Heimbach, Stefanie and Forstner, Andreas J. and
                      Streit, Fabian and Witt, Stephanie H. and Kircher, Tilo and
                      Dannlowski, Udo and Scholz, Markus and Riedel-Heller, Steffi
                      G. and Grabe, Hans J. and Baune, Bernhard T. and Berger,
                      Klaus},
      title        = {{A} meta-analysis of genome-wide studies of resilience in
                      the {G}erman population},
      journal      = {Molecular psychiatry},
      volume       = {30},
      number       = {2},
      issn         = {1359-4184},
      address      = {[London]},
      publisher    = {Springer Nature},
      reportid     = {DZNE-2025-00219},
      pages        = {497 - 505},
      year         = {2025},
      abstract     = {Resilience is the capacity to adapt to stressful life
                      events. As such, this trait is associated with physical and
                      mental functions and conditions. Here, we aimed to identify
                      the genetic factors contributing to shape resilience. We
                      performed variant- and gene-based meta-analyses of
                      genome-wide association studies from six German cohorts (N =
                      15822) using the 11-item version of the Resilience Scale
                      (RS-11) as outcome measure. Variant- and gene-level results
                      were combined to explore the biological context using
                      network analysis. In addition, we conducted tests of
                      correlation between RS-11 and the polygenic scores (PGSs)
                      for 12 personality and mental health traits in one of these
                      cohorts (PROCAM-2, N = 3879). The variant-based analysis
                      found no signals associated with resilience at the
                      genome-wide level (p < 5 × 10-8), but suggested five
                      genomic loci (p < 1 × 10-5). The gene-based analysis
                      identified three genes (ROBO1, CIB3 and LYPD4) associated
                      with resilience at genome-wide level (p < 2.48 × 10-6) and
                      32 potential candidates (p < 1 × 10-4). Network analysis
                      revealed enrichment of biological pathways related to
                      neuronal proliferation and differentiation, synaptic
                      organization, immune responses and vascular homeostasis. We
                      also found significant correlations (FDR < 0.05) between
                      RS-11 and the PGSs for neuroticism and general happiness.
                      Overall, our observations suggest low heritability of
                      resilience. Large, international efforts will be required to
                      uncover the genetic factors that contribute to shape trait
                      resilience. Nevertheless, as the largest investigation of
                      the genetics of resilience in general population to date,
                      our study already offers valuable insights into the biology
                      potentially underlying resilience and resilience's
                      relationship with other personality traits and mental
                      health.},
      keywords     = {Humans / Genome-Wide Association Study: methods /
                      Resilience, Psychological / Germany / Multifactorial
                      Inheritance: genetics / Male / Female / Polymorphism, Single
                      Nucleotide: genetics / Personality: genetics / Mental Health
                      / Adult / Cohort Studies / Middle Aged},
      cin          = {AG Grabe},
      ddc          = {610},
      cid          = {I:(DE-2719)5000001},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39112778},
      pmc          = {pmc:PMC11746137},
      doi          = {10.1038/s41380-024-02688-1},
      url          = {https://pub.dzne.de/record/276147},
}