000276152 001__ 276152
000276152 005__ 20250209000710.0
000276152 0247_ $$2doi$$a10.1002/trc2.70037
000276152 0247_ $$2pmid$$apmid:39839078
000276152 0247_ $$2pmc$$apmc:PMC11747987
000276152 0247_ $$2altmetric$$aaltmetric:173216731
000276152 037__ $$aDZNE-2025-00224
000276152 041__ $$aEnglish
000276152 082__ $$a610
000276152 1001_ $$aUnderwood, Benjamin R$$b0
000276152 245__ $$aData-driven discovery of associations between prescribed drugs and dementia risk: A systematic review.
000276152 260__ $$aHoboken, NJ$$bWiley$$c2025
000276152 3367_ $$2DRIVER$$aarticle
000276152 3367_ $$2DataCite$$aOutput Types/Journal article
000276152 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1738663429_16422$$xReview Article
000276152 3367_ $$2BibTeX$$aARTICLE
000276152 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000276152 3367_ $$00$$2EndNote$$aJournal Article
000276152 520__ $$aRecent clinical trials on slowing dementia progression have led to renewed focus on finding safer, more effective treatments. One approach to identify plausible candidates is to assess whether existing medications for other conditions may affect dementia risk. We conducted a systematic review to identify studies adopting a data-driven approach to investigate the association between a wide range of prescribed medications and dementia risk. We included 14 studies using administrative or medical records data for more than 130 million individuals and 1 million dementia cases. Despite inconsistencies in identifying specific drugs that may modify Alzheimer's or dementia risk, some themes emerged for drug classes with biological plausibility. Antimicrobials, vaccinations, and anti-inflammatories were associated with reduced risk, while diabetes drugs, vitamins and supplements, and antipsychotics were associated with increased risk. We found conflicting evidence for antihypertensives and antidepressants. Drug repurposing for use in dementia is an urgent priority. Our findings offer a basis for prioritizing candidates and exploring underlying mechanisms.·We present a systematic review of studies reporting association between drugs prescribed for other conditions and risk of dementia including 139 million people and 1 million cases of dementia.·Our work supports some previously reported associations, for example, showing decreased risk of dementia with drugs to treat inflammatory disease and increased risk with antipsychotic treatment.·Antimicrobial treatment was perhaps more surprisingly associated with decreased risk, supportive of recent increased interest in this potential therapeutic avenue.·Our work should help prioritize drugs for entry into adaptive platform trials in Alzheimer's disease and will serve as a useful resource for those investigating drugs or classes of drugs and risk of dementia.
000276152 536__ $$0G:(DE-HGF)POF4-353$$a353 - Clinical and Health Care Research (POF4-353)$$cPOF4-353$$fPOF IV$$x0
000276152 588__ $$aDataset connected to CrossRef, PubMed, , Journals: pub.dzne.de
000276152 650_7 $$2Other$$aAlzheimer's disease
000276152 650_7 $$2Other$$adementia
000276152 650_7 $$2Other$$adrug repurposing
000276152 650_7 $$2Other$$aelectronic health records
000276152 650_7 $$2Other$$amachine learning
000276152 650_7 $$2Other$$amedications
000276152 650_7 $$2Other$$apharmacoepidemiology
000276152 7001_ $$aLourida, Ilianna$$b1
000276152 7001_ $$aGong, Jessica$$b2
000276152 7001_ $$aTamburin, Stefano$$b3
000276152 7001_ $$aTang, Eugene Yee Hing$$b4
000276152 7001_ $$aSidhom, Emad$$b5
000276152 7001_ $$aTai, Xin You$$b6
000276152 7001_ $$0P:(DE-2719)2810555$$aBetts, Matthew J$$b7$$udzne
000276152 7001_ $$aRanson, Janice M$$b8
000276152 7001_ $$aZachariou, Margarita$$b9
000276152 7001_ $$aOlaleye, Olajide E$$b10
000276152 7001_ $$aDas, Saswati$$b11
000276152 7001_ $$aOxtoby, Neil P$$b12
000276152 7001_ $$aChen, Shanquan$$b13
000276152 7001_ $$aLlewellyn, David J$$b14
000276152 7001_ $$aPhenotyping, Deep Dementia$$b15$$eCollaboration Author
000276152 773__ $$0PERI:(DE-600)2832891-7$$a10.1002/trc2.70037$$gVol. 11, no. 1, p. e70037$$n1$$pe70037$$tAlzheimer's & dementia / Translational research & clinical interventions$$v11$$x2352-8737$$y2025
000276152 8564_ $$uhttps://pub.dzne.de/record/276152/files/DZNE-2025-00224%20SUP1.pdf
000276152 8564_ $$uhttps://pub.dzne.de/record/276152/files/DZNE-2025-00224%20SUP2.pdf
000276152 8564_ $$uhttps://pub.dzne.de/record/276152/files/DZNE-2025-00224.pdf$$yOpenAccess
000276152 8564_ $$uhttps://pub.dzne.de/record/276152/files/DZNE-2025-00224%20SUP1.pdf?subformat=pdfa$$xpdfa
000276152 8564_ $$uhttps://pub.dzne.de/record/276152/files/DZNE-2025-00224%20SUP2.pdf?subformat=pdfa$$xpdfa
000276152 8564_ $$uhttps://pub.dzne.de/record/276152/files/DZNE-2025-00224.pdf?subformat=pdfa$$xpdfa$$yOpenAccess
000276152 909CO $$ooai:pub.dzne.de:276152$$pdnbdelivery$$pdriver$$pVDB$$popen_access$$popenaire
000276152 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2810555$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b7$$kDZNE
000276152 9131_ $$0G:(DE-HGF)POF4-353$$1G:(DE-HGF)POF4-350$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lNeurodegenerative Diseases$$vClinical and Health Care Research$$x0
000276152 9141_ $$y2025
000276152 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2025-01-07
000276152 915__ $$0LIC:(DE-HGF)CCBY4$$2HGFVOC$$aCreative Commons Attribution CC BY 4.0
000276152 915__ $$0StatID:(DE-HGF)0112$$2StatID$$aWoS$$bEmerging Sources Citation Index$$d2025-01-07
000276152 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bALZH DEMENT-TRCI : 2022$$d2025-01-07
000276152 915__ $$0StatID:(DE-HGF)3001$$2StatID$$aDEAL Wiley$$d2025-01-07$$wger
000276152 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ$$d2024-08-08T17:09:24Z
000276152 915__ $$0StatID:(DE-HGF)0501$$2StatID$$aDBCoverage$$bDOAJ Seal$$d2024-08-08T17:09:24Z
000276152 915__ $$0StatID:(DE-HGF)0700$$2StatID$$aFees$$d2025-01-07
000276152 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2025-01-07
000276152 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5$$d2025-01-07
000276152 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
000276152 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bDOAJ : Anonymous peer review$$d2024-08-08T17:09:24Z
000276152 915__ $$0StatID:(DE-HGF)0561$$2StatID$$aArticle Processing Charges$$d2025-01-07
000276152 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2025-01-07
000276152 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2025-01-07
000276152 9201_ $$0I:(DE-2719)5000006$$kAG Düzel$$lClinical Neurophysiology and Memory$$x0
000276152 980__ $$ajournal
000276152 980__ $$aVDB
000276152 980__ $$aUNRESTRICTED
000276152 980__ $$aI:(DE-2719)5000006
000276152 9801_ $$aFullTexts