%0 Journal Article
%A Lopes, Leonor
%A Jiao, Fangyang
%A Xue, Song
%A Pyka, Thomas
%A Krieger, Korbinian
%A Ge, Jingjie
%A Xu, Qian
%A Fahmi, Rachid
%A Spottiswoode, Bruce
%A Soliman, Ahmed
%A Buchert, Ralph
%A Brendel, Matthias
%A Hong, Jimin
%A Guan, Yihui
%A Bassetti, Claudio L A
%A Rominger, Axel
%A Zuo, Chuantao
%A Shi, Kuangyu
%A Wu, Ping
%T Dopaminergic PET to SPECT domain adaptation: a cycle GAN translation approach.
%J European journal of nuclear medicine and molecular imaging
%V 52
%N 3
%@ 1619-7070
%C Heidelberg [u.a.]
%I Springer-Verl.
%M DZNE-2025-00229
%P 851 - 863
%D 2025
%X Dopamine transporter imaging is routinely used in Parkinson's disease (PD) and atypical parkinsonian syndromes (APS) diagnosis. While [11C]CFT PET is prevalent in Asia with a large APS database, Europe relies on [123I]FP-CIT SPECT with limited APS data. Our aim was to develop a deep learning-based method to convert [11C]CFT PET images to [123I]FP-CIT SPECT images, facilitating multicenter studies and overcoming data scarcity to promote Artificial Intelligence (AI) advancements.A CycleGAN was trained on [11C]CFT PET (n = 602, 72
%K Humans
%K Tomography, Emission-Computed, Single-Photon: methods
%K Positron-Emission Tomography: methods
%K Parkinson Disease: diagnostic imaging
%K Parkinson Disease: metabolism
%K Image Processing, Computer-Assisted: methods
%K Male
%K Female
%K Dopamine: metabolism
%K Deep Learning
%K Middle Aged
%K Dopamine Plasma Membrane Transport Proteins: metabolism
%K Aged
%K Tropanes
%K CFT PET (Other)
%K Cycle GAN (Other)
%K Domain adaptation (Other)
%K FP-CIT SPECT (Other)
%K Parkinson’s disease (Other)
%K Dopamine (NLM Chemicals)
%K Dopamine Plasma Membrane Transport Proteins (NLM Chemicals)
%K 2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane (NLM Chemicals)
%K Tropanes (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:39557690
%R 10.1007/s00259-024-06961-x
%U https://pub.dzne.de/record/276157